Article Text

THU0316 Ischemic Heart Disease among SLE Patients: A Case-Control Study
  1. A. Abu Much1,2,
  2. A. Watad1,
  3. D. Bracco2,
  4. A.D. Cohen3,
  5. H. Amital1
  1. 1Department of Medicine “B”, Sheba Medical Center, Tel hashomer
  2. 2Sackler Faculty of Medicine, Tel Aviv university
  3. 3Clalit Health Services, Tel Aviv, Israel


Background Ischemic heart disease (IHD) is a well identified cause of mortality in SLE patients due to accelerated premature atherosclerosis attributed to both traditional cardiovascular risk factors and to the inflammatory effect of SLE itself (1,2).

Objectives To investigate the incidence and prevalence of IHD among Middle Eastern SLE patients derived from a large, national real-life database.

Methods Using data from the largest HMO in Israel, the Clalit Health Services, we selected for patients with SLE. These patients were compared with age and sex matched controls with regards to the prevalence of IHD in a case-control study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis.

Results The study included 5,018 patients with SLE and 25,090 age and sex-frequency matched controls. The prevalence of IHD in patients with SLE was increased compared to controls (11.3% and 3.1%, respectively, P<0.001). In a multivariate analysis SLE was associated with IHD (OR 3.77, 95% confidence interval 3.34–4.26).

Logistic regression for IHD (n=30,108)

Conclusions Our data supports that SLE is an independent risk factor for IHD. When evaluating by gender, the risk seems even more substantial in females.

  1. Petri MA, Kiani AN, Post W, Christopher-Stine L, Magder LS. Lupus Atherosclerosis Prevention Study (LAPS).Ann Rheum Dis. 2011;70:760–5

  2. Romero-Díaz J, Vargas-Vόracková F, Kimura-Hayama E, Cortázar-Benítez LF,Gijόn-Mitre R, Criales S, Cabiedes-Contreras J, Iñiguez-Rodríguez Mdel R,Lara-García EA, Núñez-Alvarez C, Llorente L, Aguilar-Salinas C, Sánchez-Guerrero J. Systemic lupus erythematosus risk factors for coronary artery calcifications. Rheumatology (Oxford). 2012;51:110–9.

Disclosure of Interest None declared

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