Calcium pyrophosphate deposition (CPPD) is generally regarded as a local joint specific phenomenon with a few reported instances of widespread polyarticular CPPD attributed to inherited disorders, severe generalised structural arthropathy, or uncommon to rare metabolic disorders like haemochromatosis, hyperparathyroidism, hypomagnesemia and hypophosphatasia. Recent research by our group has demonstrated that chondrocalcinosis (a surrogate for CPPD) occurs due to a systemic predisposition. We have also demontrated that the association between chondrocalcinosis and osteoarthirtis is joint specific and that chondrocalcinosis at both index and distant joints modifies the radiographic phenotype of lower limb large joint osteoarthritis. For instance knee chondrocalcinosis and chondrocalcinosis at distant joints (in the absence of any knee chondrocalcinosis) associate with attrition in knees with osteoarthritis. In this lecture I will describe the pathogenesis of CPPD, review the research which demonstrates that there is a systemic predisposition to CPPD, and that its interactions with osteoarthritis are joint specific.
Disclosure of Interest None declared