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SP0096 Optimization of MTX in RA Treatment
  1. M. Schiff
  1. University of Colorado, Colorado, United States

Abstract

EULAR and ACR guidelines agree that Methotrexate (MTX) should be the first part of Rheumatoid Arthritis therapy if there is no contraindication As stated in the EULAR guidelines “MTX should be part of the first treatment strategy in patients with active RA… and thus continues to serve as an anchor drug in RA.”

After decades of successful use of MTX the ideal way to optimize MTX is still being discussed.

This presentation will address MTX as the current anchor drug in RA and how to better optimize its dosing for best patient care. Recent EULAR, ACR presentations will be highlighted.

The pharmokinetics will be illustrated from recent Annals of Rheumatic disease papers to help clinicians optimize MTX. Genetic concerns will be addressed and how they might impact the clinical utility and future dosing of MTX.

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  6. Schiff MH et al: Oral to Subcutaneous Methotrexate. Dose Conversion Strategies in the Treatment of Rheumatoid Arthritis. Oral presentation: ACR 2015.

  7. Müller, R et al: Effectiveness, tolerability, and safety of subcutaneous methotrexate in early rheumatoid arthritis: A retrospective analysis of real-world data from the St. Gallen cohort. Semin Arthritis Rheum. 2015 Aug;45(1):28–34 DOI: http://dx.doi.org/10.1016/j.semarthrit.2015.02.009

Disclosure of Interest None declared

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