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THU0055 Bone Resorption Was Correlated with Radiologic Progression in Postmenopausal Women with Rheumatoid Arthritis
  1. J. Huang1,
  2. S. Cui2,
  3. J. Jiang3,
  4. Y. Xie1,
  5. L. Zhang1
  1. 1Rheumatology
  2. 2Clinical Biochemistry Department
  3. 3Radiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China


Background Rheumatoid arthritis (RA) itself is associated with osteoporosis that may be localized or generalized. Joint inflammation in RA induces local periarticular osteoporosis. And the bone loss in the hands and generalized osteoporosis was reported to be correlated.

Objectives To determine the levels of bone turnover markers in patients with rheumatoid arthritis (RA) and the correlation with disease activity index, bone mineral density (BMD) and radiographic progression.

Methods Sixty-eight postmenopausal women with RA were recruited in our study. Serologic measurement including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF) and anti-cyclic citrullinated peptid (anti-CCP) were analyzed. Calcium, vitamin D, bone alkaline phosphatase (BAP) β-crosslaps were also detected. Bone mineral density (BMD, g/cm2) was measured at the lumbar spine and the left femoral neck by dual-energy X-ray absorptiometry (DXA). DAS28 and Sharp score were separately calculated for disease activity and radiographic progression evaluation. Spearman correlation analysis was conducted between clinical biomarkers and disease indexes.

Results The overall rate of patient with abnormal BMD was 94.12%, with osteopenia 29.41% (20/68) and osteoporosis 64.71% (44/68), respectively. ESR, CRP and DAS28 was significantly correlated with each other showing consistent disease activity (p<0.05). Serum β-crosslaps level (452.87±202.40 ug/l) was not correlated with any of disease acidity markers (p all >0.05) and positively correlated with Sharp score (150.76±59.71) in postmenopausal women with RA (r=0.776, p=1×10–6).

Conclusions Osteopenia and osteoporosis was predominant in RA which might be related to disease activity and/or structural damage. β-crosslaps implies radiographic progression instead of disease activity.

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  5. Hall GM, Spector TD, Delmas PD. Markers of bone metabolism in postmenopausal women with rheumatoid arthritis. Effects of corticosteroids and hormone replacement therapy. Arthritis Rheum 1995;38(7):902–6.

Disclosure of Interest None declared

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