Background Rheumatoid arthritis (RA) is a prototypical autoimmune disease, characterized by the symmetric inflammation in multiple joints, leading to progressive destruction of joints. Glycated albumin (GA) is a newly suggested parameter for the glycemic status. GA was reported to be correlated with inflammatory burdens such as (C-reactive protein) CRP and inflammatory cytokines levels [1,2].
Methods We consecutively screened 250 RA patients in this study, and finally analyzed data of 205 RA patients. We collected 12 hourfasting blood samples and performed laboratory tests. In this study, we used disease activity score (DAS) 28 using both erythrocyte sedimentation rate (ESR) (DAS28-ESR) and CRP (DAS28-CRP), and we defined DAS28 >3.2 as active RA.
Results Patients with active RA showed significantly higher GA level than those with inactive RA (13.8 ± 1.8 vs. 12.8 ± 1.4%, P<0.001 (DAS28-ESR) and 14.4 ± 1.7 vs. 13.0 ± 1.5%, P<0.001 (DAS28-CRP)). Patients with active RA had significantly higher alkaline phosphatase (ALP) level than those with inactive RA (P=0.003 (DAS28-ESR) and P=0.033 (DAS28-CRP)). On multivariate logistic regression analysis, GA ≥12.95%, CRP ≥1.65 mg/L and ALP ≥60.5 IU/L were independent predictors of active RA based on DAS28-ESR (OR 4.881, P<0.001, OR 12.972, P<0.001, and OR 3.573, P=0.001). Also GA ≥13.95% could independently predict active RA based on DAS28-CRP better than ESR ≥43.5 mm/hr (OR 6.399, P<0.001 vs. OR 4.509, P<0.001), but ALP ≥60.5 IU/L could not.
Conclusions GA level increased with disease activity in rheumatoid factor positive RA patients with normal laboratory results, who had no medical history. GA level showed the potential to predict active RA, comparable with ESR and CRP.
Pu LJ, Lu L, Xu XW, Zhang RY, Zhang Q, Zhang JS, et al.Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes. Cardiovasc Diabetol 2006;5:27.
Lu L, Pu LJ, Xu XW, Zhang Q, Zhang RY, Zhang JS, et al. Association of serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-alpha with the severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus. Clin Biochem 2007;40:810–6.
Disclosure of Interest None declared