An individually tailored diagnosis and therapy (theragnostic) could be beneficial in chronic, systemic, inflammatory autoimmune diseases like rheumatoid arthritis. The destructive nature of the disease, resulting in irreversible damages of cartilage and bone, demonstrates the urgent need for a very early diagnosis. Promising candidates for such a tool are represented by nanoparticles which have been intensively investigated over the last 20 years for various in vitro and in vivo biomedical applications. For example, nanoparticles are already in use as contrast enhancer for magnetic resonance imaging due to their favorable physicochemical properties and their biocompatibility. Further developments like surface modifications are ongoing. In order to permit the medical application of nanoparticles safety aspects need consideration.
The collaborative project NanoDiaRA was funded by the European Union and focused on the “Development of novel nanotechnology based diagnostic systems for Rheumatoid Arthritis and Osteoarthritis”. Within the project, a novel generation of superparamagnetic iron oxide nanoparticles (SPION) was developed and their effect on human immune cell survival and activity was analyzed. The nanoparticles were modified stepwise until there was no negative influence of the improved type of SPION on human immune cells. Finally, the resulting generation of nanoparticles has been demonstrated to be suitable within the human system and, therefore, represent a promising tool for theragnostic in rheumatic diseases.
Disclosure of Interest None declared