Background Psoriasis is a known risk factor of cardiovascular disorders in addition to traditional risk factors such as diabetes mellitus (DM). However, the association between psoriasis and DM is unclear.
Objectives To quantify the risk by comparing the incidence of DM between patients with psoriasis and the general population in Taiwan.
Methods The study cohort consisted of two populations. The first population is the whole patients first diagnosed with psoriasis in 2000 in Taiwan, and the second population is a nationally representative cohort of 1,000,000 individuals from the Longitudinal Health Research Database in 2000. Those who younger than age of 10 or had DM before 2000 were excluded from analysis. They were followed from 2000 until the occurrence of DM, death or 31 December 2012. Incidence rates of DM were calculated. Poisson regression was used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for DM, adjusted for age, gender and pre-existing comorbidity.
Results The study cohort comprised 756,333 subjects with a mean follow-up of 11.27 years; among them 15,099 patients with incident psoriasis were identified. Patients with psoriasis had a higher comorbidity of renal disease (1.48%), congestive heart failure (0.91%), cardiac dysrhythmia (1.82%), cerebrovascular disease (2.74%) and peripheral vascular disease (0.94%) than the general population. The incidence rate for DM was 2.04 (95% CI, 2.01–2.08) per 100 person-years for psoriasis patients comparing to 1.10 (95% CI 1.03–1.16) per 100 person-year in the general population. The adjusted IRR of incident DM was 1.34 (95% CI 1.29–1.38) for patients with psoriasis.
Conclusions Patients with psoriasis has an increased risk for DM. A vigilant monitoring for DM in patients with incident psoriasis is warranted to reduce long-term cardiovascular risks.
Disclosure of Interest None declared
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