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AB0982 Dichotomous Scoring of Ra Ultrasound Inflammation Demonstrates Good Responsiveness Compared To Semi-Quantitative Scoring When Using Novel Joint Selection Methods
  1. Y.K. Tan1,2,3,
  2. J.C. Allen Jr4,
  3. W.K. Lye4,
  4. P.G. Conaghan5,6,
  5. L.C. Chew1,2,3,
  6. J. Thumboo1,2,3
  1. 1Department of Rheumatology and Immunology, Singapore General Hospital
  2. 2Duke-NUS Graduate Medical School
  3. 3Yong Loo Lin School of Medicine, National University of Singapore
  4. 4Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore
  5. 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds
  6. 6NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom


Background Novel joint selection methods using semi-quantitative scoring (SQS) of ultrasound (US) joint inflammation (power Doppler (PD) vascularity and grey-scale synovial hypertrophy (GSSH)) have shown good sensitivity to change versus existing methods and DAS28 in RA (1). However SQS may have more variability than dichotomous scoring (DS) as SQS requires grading across multiple categories.

Objectives Compare responsiveness of DS of US joint inflammation versus SQS using 2 novel and 2 existing joint selection methods.

Methods Novel methods were Individualized US [IUS], which selects up to 7 or 12 most inflamed joints on US and Individualized Composite-US [ICUS], which additionally considers joint symptoms. Existing methods were a pre-defined 7-joint count and a 12-joint count derived from an US data reduction method. PD vascularity and GSSH at the joints were scored via a DS system [USDSS] as Y/N or via a SQS system [USSQS] on a 0–3 severity scale. Both systems scored tenosynovitis (PD and GS changes), tender and swollen joints as Y/N. Joint pain was scored as Y/N (with USDSS) or using a 0–3 severity scale (with USSQS). Responsiveness at 3 months was measured using the standardized response mean (SRM). Relative gains in SRM magnitude (SRM-Gains) were reported comparing novel to existing methods.

Results 20 RA subjects (mean DAS28 at baseline and 3-months =4.68 and 4.19, respectively) starting/escalating on DMARDs and corticosteroid therapy were followed for 3 months. SRMs using existing methods were modest for both USDSS and USSQS (ranged from 0.30 to 0.49). SRMs ranged from 0.94 to 1.06 using novel methods with both systems. There were substantial SRM-Gains (ranged from 1.94 to 3.47) for both systems using ICUS and IUS with the 7 or 12 joint approaches.

Table 1.

Results of USDSS and USSQS

Conclusions Results of this small study suggest USDSS may be as responsive as USSQS (both had substantial SRM-Gains) using novel joint selection methods.

  1. Tan YK et al. J Rheumatol. 2016;43(1):34–7

Acknowledgement NCS grant and Estate of Tan Sri Khoo Teck Puat for funding support and the NUS

Disclosure of Interest None declared

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