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AB0925 Serum Galectin-3 and TGF-Beta Levels in Patients with Sarcoidosis
  1. S. Kobak1,
  2. M. Akyildiz2,
  3. A. Gokduman2,
  4. T. Atabay3,
  5. H. Vural2
  1. 1Rheumatology
  2. 2Biochemistry
  3. 3Physiology, Sifa University Faculty of Medicine, Izmir, Turkey

Abstract

Background Sarcoidosis is a chronic granulomatous disease characterized by non-caseating granuloma formation. Galectin-3 is a multifunctional protein involved in many biological processes such as fibrosis, angiogenesis and immune activation.

Objectives To determine the serum galectin-3 and transforming growth factor-beta (TGF-beta) levels in patients with sarcoidosis and to determine a possible correlation with clinical findings.

Methods Forty-four biopsy proven sarcoidosis patients followed at a single center and age and sex matched 41 healthy volunteers were included in the study. Demographic, clinical, laboratory and radiological data were recorded in all patients. Serum galectin-3 and TGF-beta levels were measured by ELISA method.

Results Among 44sarcoidosis patients 13 (29.5%) were male and 31 (70.5%) were female. Average patient age was 47.4 years, mean disease duration was 3.2year. Twenty-one (47.7%) patients had erythema nodosum, three (6.8%) had uveitis, 40 (90.9%) had arthralgia, 23 (52.3%) had ankle arthritis, 15 (34.1%) had enthesitis. Laboratory evaluation showed increased serum ACE level in 24 (54.5%) patients, increased serum calcium level in 11 (25%) patients, increased serum D3 level in 5 (11.4%) patients, increased ESR and CRP levels in 22 (50%) and 23 (52.3%) patients, respectively. Serum galectin-3 level were similar in the sarcoidosis patients and the control group (p=0.977). No relationship were found between serum galectin-3 level and clinical and laboratory findings (p>0.05). Serum TGF-beta level were higher in patients with sarcoidosis compared with the control group (p=0.005). Serum TGF-beta level was associated only with enthesitis and arthralgia (p=0.006,p=0.02), while no correlation were detected with other disease features (p>0.05).

Conclusions We found high level of serum TGF-beta, but normal level of galectin-3 in patients with sarcoidosis. These findings suggest that TGF-beta play an important role in the pathogenesis of sarcoidosis. to, there is a need for new Multicenter prospective studies are needed to illuminate the possible relationship between serum galectin-3 and sarcoidosis.

Disclosure of Interest None declared

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