Background Alcohol is known to be associated with the occurrence of hyperuricemia. Facial flushing responses to drinking appears to be due to the intelerance to alcohol. This study assessed the role of the facial flushing response in the relationship between alcohol consumption and hyperuricemia.
Objectives The subjects were 845 Korean adult males (463 non-flushers, 382 flushers) who had undergone a health check-up at an university hospital.
Methods Data were collected from the subjects' medical records. After Adjusted for high density lipoprotein cholesterol, hypertension, diabetes, log-transformed triglyceride, log-transformed estimated glomerular filtration rate, body mass index, a logistic regression analysis was used to calculate the risk of hyperuricemia with drinks per week as compared with non-drinkers of each group.
Results In non-flushing group, the risk of hypeuricemia was significantly increased when non-flushers consumed more than 8 drinks per week (odds ratio [OR], 2.61; 95% confidence interval [CI] 1.05–6.51). In contrast, a higher risk of hyperuricemia was associated with flushers who consumed even <2 drinks (OR, 3.33; 95% CI, 1.01–10.98) per week.
Conclusions These findings suggest that the amount of drinking associated with the risk of hyperuricemia in flushers was lower than in non-flushers.
Zhang W, Doherty M, Bardin T, Pascual E, Barskova V, Conaghan P, et al. EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2006;65:1312–24.
Jung JG, Kim JS, Yoon SJ, Oh MK. Relationships among alcohol consumption, facial flushing response, and metabolic syndrome in healthy men. Ann Epidemiol 2012;22:480–6.
Disclosure of Interest None declared