Background The hormone adiponectin is an indispensable component in the regulation of energy homeostasis and maintaining optimal lipid profile. It was found that low levels of adiponectin may be regarded as a predictor of metabolic syndrome. Despite the fact that adiponectin has an effect on energy homeostasis and is an anti-inflammatory agent, its main role is antiatherogenic effect and influence on the lipid profile body.
Objectives to study the contents of adiponectin in the blood of children with rheumatic diseases.
Methods Indicators serum lipid spectrum (total cholesterol, triglycerides, and HDL cholesterol) were studied at a biochemical analyzer. The concentration of adiponectin and serum CRP levels determined by ELISA.
Statistical analysis was performed using the software package Statistica 8.0 (“StatSoft, Inc.”, USA).
Results The study involved 54 children with juvenile idiopathic arthritis (JIA), 18 children with systemic lupus erythematosus (SLE) and 24 children with juvenile scleroderma (JS). Most of the children receiving long-term glucocorticoid and immunosuppressive therapy. 28 children with JIA, 9 children with SLE and 11 children with JS were overweight. Obesity is defined in 13 children with JIA, 8 children with SLE and 5 children with JS. When comparing the average concentrations of adiponectin according to the body mass index (BMI) found that with an increase in this index decreased adiponectin content in blood. Adiponectin level was significantly lower in obese children (10,8±4,6 mg/ml) compared with children with overweight (13,2±5,3 mg/ml) and children with normal body weight (16,4±4,1 mg/ml). In healthy children adiponectin content was 21,3±5,7 mg/ml. There was a significant negative correlation of adiponectin with body mass index (r=-0,36), glucose concentrations (r=-0,29), C-reactive protein (r=-0,31), the levels of blood pressure (r=-0.34) and positive to the level of high density lipoprotein (r=0.26).
Conclusions The negative correlation between the level of adiponectin blood concentration of C-reactive protein and a positive correlation with the level of HDL indicates the probable anti-inflammatory properties of adiponectin and its protective effect against the development of atherosclerosis in children with rheumatic diseases.
Acknowledgement This study would not have been possible without the collaboration of numerous Belarusian pediatric rheumatologists, patients and their parents.
Disclosure of Interest None declared