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AB0774 The Effect of 1 Year Oral Ibandronate on Bone Mineral Density and HR QoL – An Outpatient Study in A Speciality Clinic in Albania
  1. B. Hebibasi
  1. Rheumatology, Policlinic of Specialities No 2, Tirana, Albania

Abstract

Background Biphosphonate use is expected to increase Bone Mineral Density (BMD) and reduce the risk of vertebral and non-vertebral fractures. This may also lead to an improvement of Health Related Quality of Life (HR QoL) in the treated patients.

Objectives To confirm the efficacy and safety of 1 year oral Ibandronate, 150 mg monthly. To analyze its effect on patients' quality of life.

Methods 140 postmenopausal patients (average age 65.2 yrs, avg age of menopause 46.8 yrs, avg years from menopause 18.3yrs) diagnosed with osteoporosis (T-score <2.5 SD) during 2014 – 2015, were given 150mg of oral Ibandronic Acid monthly and supplements of Calcium and Vitamin D daily. BMD was measured with DXA HOLOGIC at baseline and after 1 year of treatment. HR QoL was assessed through EQ – VAS at baseline and after 1 year.

Results 132 patients completed the study. 5 patients (3.5%) withdrew from the study because of G-I complications, 3 patients (2.1%) did not repeat the DXA. A statistically significant increase of BMD was noted in the lumbar spine, (4.7%, p<0.001) and in the hip region (2.9%, p<0.001). Patients' perceived health also improved on a Visual Analogue Scale. Median 74 IR 60: 89 compared to median 70 IR 51:86 at the beginning of the study.

Conclusions Oral Ibandronate is safe and effective in increasing BMD in both Hip and lumbar spine. Apart from reducing the risk of fractures, it helps to improve the patients' perceived Health Related Quality of Life.

Disclosure of Interest None declared

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