Background Polio is a devastating infectious disease that causes paralysis and severe muscular atrophy. When any of the legs is affected, a low aBMD at the corresponding hip is a common finding in DXA measurement.
Objectives to study the influence of polio consequences on volumetric bone density and cortical thickness using the 3D-DXA technology.
Methods 22 patients of both sexes suffering post-polio syndromes (mean age 57±uffering pos were scanned using a GE iDXA system and both proximal femurs were reconstructed using the 3D-DXA technology. 3D-DXA is based on the registration of a 3D statistical model of the femoral shape and density onto the 2D DXA image and provides measurements of volumetric BMD (vBMD) and BMCof the trabecular and cortical bone as well as a quantification of the cortical thickness. The measurements at the leg affected by polio were compared by t-test with those at the non-affected leg.
Results Trabecular BMC was 22% lower (-1.8 g, p<0.01) and cortical BMC 19% lower (-2.9 g, p<0.01) at the polio leg (total hip region). Similar findings were observed for the vBMD: 18% decrease (-0.020 g/cm3, p<0.01) at the trabecular region and a 2.3% decrease for the cortical bone (-0.024 g/cm3, p<0.01). The proximal femur volume was also inferior (-12%, -9 cm3, p<0.01). The cortical thickness was thinner at the polio leg (-12%, -0.2 mm, p<0.01).
Conclusions A long period of decreased of mechanical charges, low muscle strength, postural imbalance has dramatic consequences on bone development. The analyses performed using the 3D-DXA technology indicates an overall impairment of cortical and trabecular BMD and a significant decrease of the cortical thickness.
Disclosure of Interest None declared