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AB0736 The Bepas Cohort: A Real-Life Multicenter Prospective Cohort of Psoriatic Arthritis in Belgium: Demographics and Baseline Characteristics
  1. K. De Vlam1,
  2. R. Lories1,
  3. S. Steinfeld2,
  4. F. Van Den Bosch3,
  5. A. Nzeusseu Toukap4,
  6. M. Malaise5,
  7. V. Taelman1,
  8. F. Van Bruwaene6,
  9. M. Van Den Berghe7,
  10. J. Lenaerts8,
  11. R. Joos9,
  12. P. Geusens10,
  13. S. Dall'Armellina11,
  14. I. Peene12,
  15. G. De Brabanter13,
  16. M. Van Den Berghe14,
  17. J. Qu15,
  18. M. Maertens16,
  19. H. Leroi17,
  20. on behalf of BEPAS
  1. 1rheumatology, University Hospitals Leuven, Leuven
  2. 2Clinique St Jean, Bruxelles
  3. 3Ugent, Gent
  4. 4rheumatology, UCL St Luc, Brussels
  5. 5rheumatology, CHU Sart Tilman, Liege
  6. 6rheumatology, Heilig Hart Ziekenhuis, Roeselaere
  7. 7rheumatology, Algemeen Stedelijk Ziekenhuis, Aalst
  8. 8Reuma instituut, Hasselt
  9. 9rheumatology, ZNA, Antwerpen
  10. 10ReumaClinic, Genk
  11. 11rheumatology, Clinique Notre Dame de Grace, Gosselies
  12. 12AZ St Jan
  13. 13rheumatology, AZ St Lucas, Brugge
  14. 14rheumatology, Grand Hopital de Charleroi, Charleroi
  15. 15rheumatology, Iris sud, Brussels
  16. 16AZ Damiaan, Oostende
  17. 17Medical Affairs Immunology, MSD Belgium, Brussels, Belgium

Abstract

Background Psoriatic arthritis (PsA) is a common form of chronic arthritis with major impact on the physical and psychosocial integrity of the patient. BEPAS (Belgian Epidemiological Psoriatic Arthritis Study) is a large prospective multicenter cohort set up in 17 Belgian rheumatology practices based in secondary and tertiary referral centers (private practice, non-academic and academic hospitals).

Objectives (1) To generate a comprehensive database to characterize the clinical presentation and the frequency of the distinct PsA subtypes; (2) to estimate the severity of disease based on disease activity scores and structural damage; (3) to estimate the impact in terms of health-related quality of life of PsA in Belgium and (4) to evaluate progression of structural damage and loss of function in patients with PsA over time.

Methods Patients with an existing or a new clinical diagnosis of PsA and fulfilling the CASPAR classification criteria were recruited. All patients gave informed consent. In the prospective study, patients are followed every year during the first 2 years with a possible extension for an additional 5 years. Demographics,clinical parameters, and data about QoL and disability were collected. X-rays of hands and feet are performed every year and axial X-rays every 2 years.

Results 461 patients (mean age: 52.79 years (±12.29), male 57%) were recruited from December 2012 to July 2014. N = number of patients with data available.

Conclusions This large cohort paints a real-life heterogeneous presentation of PsA in academic and non-academic centers in Belgium and contrast with other cohorts which are mainly academic cohorts. Further data collection will facilitate clinical and outcome studies iabout the impact and natural history of PsA in Belgium.

Disclosure of Interest K. De Vlam Grant/research support from: MSD Belgium, R. Lories Grant/research support from: MSD Belgium, S. Steinfeld Grant/research support from: MSD Belgium, F. Van Den Bosch Grant/research support from: MSD Belgium, A. Nzeusseu Toukap Grant/research support from: MSD Belgium, M. Malaise Grant/research support from: MSD Belgium, V. Taelman Grant/research support from: MSD Belgium, F. Van Bruwaene Grant/research support from: MSD Belgium, M. Van Den Berghe Grant/research support from: MSD Belgium, J. Lenaerts Grant/research support from: MSD Belgium, R. Joos Grant/research support from: MSD Belgium, P. Geusens Grant/research support from: MSD Belgium, S. Dall'Armellina Grant/research support from: MSD Belgium, I. Peene Grant/research support from: MSD Belgium, G. De Brabanter Grant/research support from: MSD Belgium, M. Van Den Berghe Grant/research support from: MSD Belgium, J. QU Grant/research support from: MSD Belgium, M. Maertens Grant/research support from: MSD Belgium, H. Leroi Employee of: MSD Belgium

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