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AB0725 Anti-Tnf-α Therapy Improves Endothelial Function and Arterial Stiffness in Patients with Moderate-To-Severe Psoriasis: A 6-Month Prospective Study
  1. C. Fernández-Díaz1,
  2. T. Pina1,
  3. A. Corrales1,
  4. R. Lόpez-Mejías1,
  5. S. Armesto2,
  6. M.A. González-Lόpez2,
  7. I. Gόmez-Acebo3,
  8. B. Ubilla1,
  9. S. Remuzgo-Martínez1,
  10. C. González-Vela4,
  11. R. Blanco1,
  12. J.L. Hernández5,
  13. J. Llorca3,
  14. J. Loricera1,
  15. M.Ά. González-Gay1
  1. 1Rheumatology
  2. 2Dermatology, Hospital Universitario Marqués de Valdecilla, IDIVAL
  3. 3Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL
  4. 4Pathology
  5. 5Internal Medicine, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

Abstract

Background The risk of CV events is closely related to the severity of the psoriasis. The presence of severe psoriasis confers an additional 6.2% absolute risk of a 10-year rate of CV events compared with the general population. Studies on anti-TNF-α therapy indicate that these agents yield a reduction in the incidence of CV events in patients with psoriasis.

Objectives To determine if the use of the anti-TNF-α monoclonal antibody adalimumab could improve endothelial function and arterial stiffness in patients with moderate-to-severe psoriasis.

Methods Prospective study on a series of consecutive patients with moderate-to-severe psoriasis who completed 6 months of therapy with adalimumab. Patients with history of cardiovascular events, diabetes mellitus, kidney disease, hypertension or body mass index ≥35 kg/m2 were excluded. Assessment of endothelial function by brachial artery reactivity measuring flow-mediated endothelial dependent vasodilatation (FMD%), and carotid arterial stiffness by pulse wave velocity (PWV) was performed at the onset of treatment (time 0) and at month 6.

Results 29 patients were studied. Anti-TNF-α adalimumab therapy yielded a significant improvement of endothelial function. The mean±standard deviation (SD) FMD% values increased from 6.19±2.44% at the onset of adalimumab to 7.46±2.43% after six months of treatment with this biologic agent (p=0.008). Likewise, following the use of adalimumab, PWV levels decreased from 6.28±1.04 m/s at the onset of adalimumab to 5.69±1.31 m/s at 6 months (p=0.03).

Conclusions Patients with moderate-to-severe psoriasis exhibit improvement of endothelial function and arterial stiffness following anti-TNF-α therapy. These findings are of potential relevance due to increased risk of cardiovascular disease in patients with severe psoriasis.

Acknowledgement The study was supported by a research grant from Abbvie Inc.

Disclosure of Interest None declared

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