Background Metabolic syndrome (MetS) increases the risk of developing cardiovascular disease at least two-fold. Various studies have suggested that MetS is associated with a state of chronic, low-grade inflammation (1).
Objectives Our aim is to show relationships between MetS and chronic low grade inflammatory diseases, to determine frequency of MetS in psoriasis and psoriatic arthritis (PsA) against romatoid arthritis (RA).
Methods 155 patients were included in this cross-sectional study. Fifty patients were psoriasis, 55 patients were PsA who was diagnosed according to the CASPAR criteria. Fifty patients were seropositive RA who was diagnosed according to the ACR/EULAR 2010 classification criteria. MetS was diagnosed by the 2005 criteria of IDF (2). Cardiovascular risk factors and MetS associated parameters were evaluated.
Results Patients mean age, age at onset disease and diagnosing age of disease in the RA group were significantly higher compared with the psoriasis and PsA (p=0,002–0,000–0,000; respectively). Duration of psoriasis was 14,7±10,2 years in the PsA group and 12,1±11,7 years in the psoriasis group (p=0,000). Duration of arthritis were significantly longer in the RA group compared with the PsA group (p=0,000).
Insulin resistance showed no significant difference between the three groups (%70, %64, %66). Elevated triglyceride levels were higher in the psoriasis and PsA compared with the RA groups (%34, %32,7, %16; respectively; p=0,045). Hypertension ratio was higher in RA than PsA and psoriasis (p=0,011) (Table 1).
CRP and HAQ which are parameters for used in the follow up disease activity were higher in the RA group.
Conclusions In all three groups, the MetS was shown to be higher than the general population. The differences between the groups could not be detected because of the small number of patients, and not equal distribution of population by age and gender.
Raychaudhuri S.K, Chatterjee S, Nguyen C, et al. Increased Prevalence of the Metabolic Syndrome in Patients with Psoriatic Arthritis. Metab Syndr and Relat Disord 2010;8(4):331–4.
Taylor W, Gladman D, Helliwell P, et al. Classification criteria for Psoriatic Arthritis: development of new criteria from a large international study. Arthritis Rheum 2006;54(8):2665–73.
Disclosure of Interest None declared