Background Vitamin D has been found to have a role in immune system function. It there's been many studies on the relationship between vitamin D and disease activity in ankylosing spondyloarthritis (AS). However, studies have concerned the groups based on vitamin D levels and determined the differences between these patients in terms of disease activity, functional status, quality of life, and others clinical parameters. The aim of this study was to compare 25-hydroxyvitamin D (25 (OH) D) in patients with AS and healthy subjects and to determine the relationship between 25 (OH) D and activity disease, functional status and quality of life.
Objectives The aim of this study is to compare 25-hydroxy-vitamin D3 (25(OH)D3) levels in AS patients with those in normal healthy subjects and to determine the relationship between 25(OH)D3 levels and AS disease activity, functional status, and quality of life.
Methods hundred twenty-five consecutive patients and 76 healthy volunteers were included in this study. After a comparison between the patient group and the control group, the group of patients was divided into normal subgroups, deficient and inadequate function of plasma 25 (OH) D3 levels for another comparison
Results Level differences 25 (OH) D between the patients and controls were statistically significant. The number of patients with AS whose rates 25 (OH) D were classified as normal, insufficient and deficient were respectively 32, 51 and 38.
The sedimentation rate (ESR), C-reactive protein (CRP) and the scores Bath AS Disease Activity Index (BASDAI) were higher in the subgroup deficiency and 25OHD deficiency (P<0.05). Bath functional scores (BASFI) and the quality of life (ASQoL) were significantly different between the subgroup with normal 25OHD levels and deficient subgroups (P<0.05). Finally the level of pain, BASDAI, ESR and CRP were inversely correlated with 25OHD (P<0.05)
Conclusions Plasma levels of 25 (OH) D may be reduced in patients with ankylosing spondyloarthritis and this can negatively affect the activity of the disease, the functional status and quality of life.
Eva Klingberg and col. Osteoporosis in ankylosing spondylitis. Arthritis Res ther.2012; 14(3): R108.
Sizheng Zhao and al. Systematic review of association between vitamin D level and susceptibility and disease activity of ankylosing spondylitis. Rheumatol 2014; 53: 1595–1603.
Disclosure of Interest None declared