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AB0577 Sleep Quality in Behcet's Disease Is Associated with Disease Activity, Depression, and Quality of Life in Korean Populations
  1. S.-S. Kim1,
  2. J. Lee2,
  3. Y.S. Kim3,
  4. H.-S. Kim4,
  5. S.-J. Hong5,
  6. H.-J. Jeong2,
  7. C.-N. Son2,
  8. J.-M. Kim2,
  9. S.-H. Kim2
  1. 1Department of Internal Medicine, Ulsan University School of Medicine, Gangwon-do
  2. 2Department of Internal Medicine, Keimyung University School of Medicine, Daegu
  3. 3Department of Internal Medicine, Chosun University Hospital, Gwangju
  4. 4Department of Internal Medicine, Soonchunhyang University Seoul Hospital
  5. 5Kyung Hee University School of Medicine, Seoul, Korea, Republic Of


Background Behcet's disease is a chronic, systemic vasculitis that can involve all sizes of blood vessels. Those complicated symptoms lead to the patient's impairment of life quality as well as psychological problems. Sleep disturbance is one of the most particular concerns in patients with Behcet's disease. It has been known that the disease activity of rheumatoid arthritis and ankylosing spondylosis is associated with the sleep quality. However, studies about the sleep quality of patients with Behcet's disease in Korean population are limited.

Objectives The purpose of this study was to find out the effects of sleep quality on Behcet's disease in Korean population. We also investigated the relationship between depression, quality of life, other clinical findings of Behcet's.

Methods The study was performed by cross-sectional design in two tertiary hospitals. We met one hundred patients with Behcet's disease, surveyed them face-to-face and conducted the chart review for more clinical informations. Sleep quality was assessed by the Korean version of Pittsburgh sleep quality index (PSQI). Disease activity of Behcet's disease was evaluated by Behcet's disease current activity form (BDCAF). Depression was assessed by the Korean version of Beck depression inventory second edition (BDI-2). Quality of life was assessed by the Korean version of the Leeds Behcet's Disease Quality of Life Measure (BDQoL).

Results Among 100 patients, median age was 51 [44.5–56.0] years, median disease duration was 77.5 [24.0–136.0] months and 31% were male. Those who met the diagnostic critera of fibromyalgia were 28 patients. The frequency of poor sleep quality (PSQI >5) was 67%. Patients with poor sleep quality tend to have higher BDI2, BDCAF and pain VAS score (P<0.001, P=0.028, and P=0.011). Female rate was significantly higher, and BDQoL was lower in poor sleeper group (P=0.004 and P<0.001). Among 7 PSQI components, daytime dysfunction was higher in patients with high disease activity (P=0.03). Total PSQI score were strongly correlated with BDCAF score, BDI-2 score, BDQoL score, and pain VAS score (P=0.02, P<0.001, P<0.001, and P<0.001, respectively).

Conclusions The low quality of sleep is associated with disease activity, depression and quality of life in Korean patients with Behcet's disease. We expect better disease control will improve the sleep quality.

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Disclosure of Interest None declared

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