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AB0567 Aortic Involvement in A Retrospective Cohort of Large Vessel Vasculitis Patients
  1. M. Bellan1,2,
  2. R. Bonometti2,
  3. A. Rossini2,
  4. A. Gibbin2,
  5. D. Sola1,2,
  6. R. Pedrazzoli2,
  7. M. Tran Minh2,
  8. M. Pirisi1,2,
  9. P.P. Sainaghi2
  1. 1Translational Medicine, Università del Piemonte Orientale UPO
  2. 2Internal Medicine Division, AOU Maggiore della Carità, Novara, Italy

Abstract

Background Large vessel vasculitis include Giant cell arteritis (GCA) and Takayasu's disease. Both these conditions can be associated with aortic inflammatory involvement, detectable by FDG-PET. Aortitis is an indicator of a more severe clinical course of disease.

Objectives We aimed to evaluate the different clinical phenotypes of large vessel vasculitis in a retrospective cohort of patients followed-up at our immunorheumatology outpatient clinic. We further aimed to identify predictors of aortic disease.

Methods We retrospectively reviewed all the clinical records of patients receiving a diagnosis of large vessel vasculitis from 1st January 2010 to 1st January 2016. Clinical, laboratory, hystopathological and imaging data were collected. Non-parametric statistical analysis was performed.

Results We recorded 42 diagnosis of large vessel vasculitis along a 5-year follow-up. Out of them 6 patients were not included in the analysis because of the lack of clinical informations. Median age of general population was 72.5 [64.0–76.0]; at onset, median ESR was 56 mm/h [44–75], while CRP was 6.9 mg/dl [3.4–12.1]. Median follow-up was 12 months [6–28]. 25/36 patients were female (69.4%); headache was the commonest onset symptom (28 cases, 77.8%), while polymyalgia rheumatic was diagnosed in 10 patients (27.8%). Half of the patients underwent a PET to rule out aortitic involvement, which was detected in 14/18 patients. The prevalence of aortic involvement was higher in male (7/11, 63.6%) than in female (7/25, 28%; p=0.04). Headache was always reported in uncomplicated GCA, while it was less frequent in aortitic patients (6/14 patients, 42.8%; p=0.0007). No differences were found with respect to age and laboratory data between patients with and without aortic involvement.

Conclusions Large vessel vasculitis are quite common diseases in elderly people. A subset of patients, characterized by aortic involvement and a more severe prognosis can be detected. The absence of headache and male sex are risk factors for aortitis.

Disclosure of Interest None declared

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