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AB0561 Heart Involvement in Patients with Eosinophilic Granulomatosis with Polyangiitis
  1. N. Nikitina1,
  2. O. Aleksandrova1,
  3. I. Nam2,
  4. N. Rodionova3,
  5. A. Rebrov1
  1. 1GBOU VPO “Saratov State Medical University name Rasumovskogo”, Saratov, Russia
  2. 2Rheumatology Department, Regional Clinical Hospital, Saratov
  3. 3Rheumatology Department, Clinical Hospital, Tambov, Russian Federation

Abstract

Background Cardiac involvement is factor of poor prognosis in eosinophilic granulomatosis with polyangiitis (EGPA). Due to current data, heart lesions in EGPA are associated with higher peripheral eosinophilia. However, data about cardiac manifestations of EGPA are limited.

The aim of the study was to evaluate the frequency of occurrence of heart involvement in patients with EGPA, and to study interrelation of heart lesion and peripheral eosinophilia and other signs of the disease.

Objectives Were analyzed 19 case histories of patients with EGPA (13 women and 6 men, mean age ± SD – 49.8±14.8 years, mean disease duration – 4.6±3.76 years). The patients were treated in Saratov regional hospital, rheumatology department.

Methods Were used clinical tests and echocardiography.

Results 7 (36.8%) patients had features of heart damage. In 2 patients were found clinical signs of myocarditis, confirmed with echocardiography (ejection fraction 48 and 50%, respectively). In 1 patient was found fibrosis of atrioventricular valves, in 3 patients – signs of valvular insufficiency, in 1 – was diagnosed coronariitis.

Eosinophils number was increased in 11 patients: in 4 from 7 patients with cardiac involvement and in 8 from 11 without heart lesion. The highest number of eosinophils was found in 2 patients with miocarditis (40 and 43%, respectively). Improvement in miocarditis and ejection fraction under the treatment was associated with decrease of eosinophils count.

In other patients during the treatment (12–24 month of follow-up) eosinophils count was normalized. There were no new features of cardiac involvement under the treatment.

Conclusions Patients with EGPA frequently have cardiac involvement. Miocarditis is associated with high eosinophils' count. Heart involvement is reversible and has no trend to progression under the treatment.

Disclosure of Interest None declared

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