Objectives To discuss the correlation between the level of serum cystatin C and lipids in patients with systemic lupus erythematosus.
Methods Used automatic biochemical analyzer to detect serum cystatin C (CysC), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein (LDL-C) and hsCRP levels in 136 cases of SLE patients and 113 cases of healthy people. Data obtained using SPSS13.0 software to carry on statistical analysis.
Results Outcome of SLE patients group comared with healthy controls, hsCRP (13.5±4.85 mg/L vs 2.03±0.88 mg/L), CysC (2.63±1.95 mg/L vs 0.85±0.37 mg/L), LDL-C (3.06±1.21 mmol/L vs 2.33±0.41 mmol/L), TC (5.32±2.63 mmol/L vs 4.02±1.67 mmol/L) and TG (1.92±0.83 mmol/L vs 1.44±0.8 mmol/L) were significantly different between the two groups. Compared with healthy controls, HDL-C (1.12±0.31 mmol/L vs 1.52±0.85 mmol/L) was decreased (P<0.01). In SLE patients group, the serum CysC level and hsCRP, TC, TG and LDL-C were positively correlated, and the level of HDL-C was negative to the level of CysC. The health control group was no significant corretation.
Conclusions Serum lipid levels of SLE patients were positive to the level of CysC. Suggest that joint detection of SLE patients serum CysC and blood lipids index is helpful to the diagnosis of SLE treatment and condition monitoring.
Ganda A, Magnusson M, Yvan-Charvet L. Mild renal dysfunction and metabolites tied to low HDL cholesterol are associated with monocytosis and atheroselerosis, Circulation, 2013,127(9):988–996
Doganer YC, Aydogan U, Aydogdu A, et al. Relationship of cystatin C with coronary artery disease and its severy. Coron Artery Dis, 2013,24(2):119–126
Disclosure of Interest None declared
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.