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AB0525 Correlation Analysis of Serum Cystatin C and Lipids Levels in Patients with Systemic Lupus Erythematosus
  1. Z. Ye,
  2. Y. Zhang,
  3. X. Luo
  1. Rheumatology Institute of Guangdong Medical College, Shenzhen, China

Abstract

Objectives To discuss the correlation between the level of serum cystatin C and lipids in patients with systemic lupus erythematosus.

Methods Used automatic biochemical analyzer to detect serum cystatin C (CysC), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein (LDL-C) and hsCRP levels in 136 cases of SLE patients and 113 cases of healthy people. Data obtained using SPSS13.0 software to carry on statistical analysis.

Results Outcome of SLE patients group comared with healthy controls, hsCRP (13.5±4.85 mg/L vs 2.03±0.88 mg/L), CysC (2.63±1.95 mg/L vs 0.85±0.37 mg/L), LDL-C (3.06±1.21 mmol/L vs 2.33±0.41 mmol/L), TC (5.32±2.63 mmol/L vs 4.02±1.67 mmol/L) and TG (1.92±0.83 mmol/L vs 1.44±0.8 mmol/L) were significantly different between the two groups. Compared with healthy controls, HDL-C (1.12±0.31 mmol/L vs 1.52±0.85 mmol/L) was decreased (P<0.01). In SLE patients group, the serum CysC level and hsCRP, TC, TG and LDL-C were positively correlated, and the level of HDL-C was negative to the level of CysC. The health control group was no significant corretation.

Conclusions Serum lipid levels of SLE patients were positive to the level of CysC. Suggest that joint detection of SLE patients serum CysC and blood lipids index is helpful to the diagnosis of SLE treatment and condition monitoring.

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Disclosure of Interest None declared

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