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AB0515 Vitamin D, IL-10, IL-17, and IL-23 as Biomarker for Disease Activity in Systemic Lupus Erythematosus
  1. T. Senturk1,
  2. B. Genc Cetin2,
  3. G. Sargin1,
  4. N. Aydin3
  1. 1Rheumatology
  2. 2Internal Medicine
  3. 3Clinical Microbiology, Adnan Menderes Universty, Aydin, Turkey

Abstract

Background Systemic Lupus Erythematosus (SLE) is a chronic, autoimmune, inflammatory disease and the prototype of multisystem autoimmune diseases. Several cytokines such as interleukin (IL)-10, IL-17, IL-23, and vitamin D have been suspected in the pathogenesis of SLE. However, the association between these cytokines, vitamin D and disease activity is unknown.

Objectives We aimed to determine the association between IL-10, IL-17, IL-23, vitamin D and SLE disease activity index (SLEDAI) score.

Methods We included 40 patients with SLE (mean age: 35.5±13.41 years, 95% female) and 20 healthy controls (mean age: 36.1±14.76 years, 70% female) in the study. Clinical and laboratory parameters and, SLEDAI score were evaluated. Serum IL-10, IL-17 and IL-23 were measured by nephelometry and vitamin D by HPLC (high-performance liquid chromatography). Mann-Whitney U and Kolmogorov-Smirnov test were used for statistical analysis. P<0.05 was accepted as statistically significant.

Results The level of vitamin D was significantly lower (p=0,003), and IL-23 was significantly higher (p=0,001) in SLE patients compared to healthy controls. There was no significant difference for IL-10 and IL-17 between both group (p>0,05). However, a significant correlation between vitamin D and disease duration (p=0,02), and between IL-23 and vitamin D (p=0,019) were found among SLE patients. Vitamin D levels were correlated with SLEDAI score and IL-23 in patients group.

Conclusions Although there are studies suppporting the role of IL-10 and IL-17 in the pathogenesis of SLE in the literature, there was no significant difference between patients and healthy controls in our study. IL-23 levels were significantly higher, whereas vitamin D levels were significantly lower in SLE patients than in the control group. Also vitamin D levels were negative correlated with duration of disease and IL-23. Levels of IL-23 may be used to evaluated the disease activity, or may be a promising therapeutic approach for SLE patients.

Disclosure of Interest None declared

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