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AB0512 Use of Nominal Group Technique To Facilitate Item Reduction for Sle Classification Criteria Development
  1. S. Johnson1,
  2. D. Khanna2,
  3. R. Cervera3,
  4. N. Costedoat-Chalumeau4,
  5. D.D. Gladman1,
  6. B.H. Hahn5,
  7. F. Hiepe6,
  8. J. Sanchez-Guerrero1,7,
  9. E. Massarotti8,
  10. D. Boumpas9,
  11. K. Costenbader8,
  12. D. Daikh10,
  13. D. Jayne11,
  14. T. Dorner12,
  15. D. Kamen13,
  16. M. Mosca14,
  17. R. Ramsey-Goldman15,
  18. J.S. Smolen16,
  19. D. Wofsy10,
  20. M. Aringer17
  1. 1University of Toronto, Toronto, Canada
  2. 2University of Michigan, Michigan, United States
  3. 3Hospital Clinic, Barcelona, Spain
  4. 4Hôpital Cochin, Paris, France
  5. 5University of California Los Angeles, Los Angeles, United States
  6. 6Charite University Hospital, Berlin, Germany
  7. 7Instituto Nacional de Ciencias Médicas y Nutriciόn Salvador Zubirán, Mexico City, Mexico
  8. 8Harvard Medical School, Boston, United States
  9. 9University of Athens, Athens, Greece
  10. 10University of California, San Francisco, United States
  11. 11Addenbrooke's Hospital, Cambridge, United Kingdom
  12. 12Charite University Hopsital, Berlin, Germany
  13. 13Medical University of South Carolina, Charleston, United States
  14. 14University of Pisa, Pisa, Italy
  15. 15Northwestern University, Chicago, United States
  16. 16Medical University of Vienna, Vienna, Austria
  17. 17University Medical Center Carl Gustav Carus, Dresden, Germany


Background Criteria for the classification of SLE are being developed with the support of EULAR and ACR. Two independent exercises (expert-based Delphi exercise and data-driven cohort evaluation of early SLE and controls) were undertaken to generate candidate criteria, and then reduce them to a smaller set.

Objectives To select a set of items that maximizes the likelihood of SLE in a person with an uncertain diagnosis.

Methods A panel of seven international SLE experts (reflecting practice in Spain, France, Germany, United States, Canada and Mexico) was asked to rank 41 candidate criteria nominated in the Delphi and cohort studies. The rankings were presented at a face-to-face meeting of the expert panel and steering committee. A consensus meeting using nominal group technique (NGT) was conducted to reduce the list of criteria for consideration. Redundant or poorly performing criteria were removed.

Results This expert panel NGT exercise reduced the candidate criteria for SLE classification from 41 to 21. The panel distinguished potential “entry criteria”, which would be required for classification, from other potential “additive criteria”, summarized in Table 1. Entry criteria were ANA by hep 2 immunofluorescence ≥1:80, and low C3 and/or low C4.

Table 1.

Additive criteria

Additional work is needed to refine definitions*, to evaluate their independence and relationships within domains, and to ascertain item weights.

Conclusions This expert panel NGT exercise resulted in 21 candidate SLE classification criteria. Refinement of definitions, ability to cluster criteria into domains and weighting of criteria will be ascertained in the next phase.

Acknowledgement This work was supported by EULAR and ACR

Disclosure of Interest None declared

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