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AB0499 Bone Mineral Density in Postmenopausal Mexican Women with Systemic Lupus Erythematosus
  1. P. Soto-Santillan1,
  2. C. Mendoza-Pinto2,
  3. S. Mendez-Martinez2,
  4. L. Leon-Vazquez2,
  5. I. Etchegaray-Morales2,
  6. J.-C. Solis-Poblano2,
  7. M.-A. Enriquez-Guerra3,
  8. A. Montiel-Jarquin4,
  9. A. Lopez-Colombo5,
  10. M. Garcia-Carrasco2
  1. 1Medicine School, Department of Immunology and Rheumatology, Benemérita Universidad Autόnoma de Puebla, Puebla, México
  2. 2Systemic Autoimmune Diseases Research Unit, Hospital General Regional No. 36, Instituto Mexicano del Seguro Social, Puebla, Mexico
  3. 3edical Sciences, Medicine School, Benemérita Universidad Autόnoma de Puebla, Puebla, México
  4. 4Division of Health Research, UMAE, HTO, Instituto Mexicano del Seguro Social, Puebla, México
  5. 5Direction of Health Education and Research, UMAE, HEP, Instituto Mexicano del Seguro Social, Puebla, México, Puebla, Mexico

Abstract

Background It is accepted that patients with SLE exhibit an increased risk for low BMD and bone fractures; nevertheless, few studies have evaluated bone disorders in Latin American population. It is the first study that has evaluated frequency and correlations of low BMD in postmenopausal mestizo Mexican women with SLE

Objectives To determine the frequency of osteoporosis and possible risk factor for low bone mineral density (BMD) in postmenopausal mestizo Latino American women with systemic lupus erythematosus (SLE)

Methods A cross-sectional study was conducted among 100 postmenopausal patients with SLE. Patients were evaluated using a questionnaire about the follow variables: age at the time of the study, age at menopause, disease duration, disease activity, damage of the disease, cumulative corticosteroid dose, and history of fracture. Lumbar spine and hip measurements of BMD were performed by dual absorptiometry. Univariate and multivariate statistical analyses were used to assess relationship between risks factor and BMD.

Results The mean age was 53.8±9.56 years and the mean SLE duration was 73.2±65 months. The mean BMD of the lumbar spine was 0.944±0.178 g/cm2 and the hip was 0.915±0.135 g/cm2. Osteopenia was present in 63% and osteoporosis in 31%. In the univariate analysis, age at the time of the study and menopause duration were associated with low BMD at the hip while age at the time of the study, menopause duration and damage of the disease were associated with low BMD at the lumbar spine. In the multiple regression analysis, low BMD in lumbar spine and hip were associated only with age (B= -0.0004, P=0.017; B= -0.0006, P= <0.05).

Conclusions Osteopenia was found in 63% and osteoporosis in 31%. Risk factor for low BMD in both total hip and lumbar spine in postmenopausal SLE women was age.

Disclosure of Interest None declared

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