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AB0480 Cancer Incidence in Systemic Lupus Erythematosus Patients
  1. M. Fernández Matilla1,
  2. E. Grau Garcia1,2,
  3. G. Poveda Marín2,
  4. C. Feced Olmos2,
  5. E. Labrador Sánchez2,
  6. F.M. Ortiz Sanjuan2,
  7. N. Fernández-Llanio3,
  8. D. Hervás Marín4,
  9. V. Fornes Ferrer4,
  10. K. Arévalo Ruales2,
  11. R. Negueroles Albuixech2,
  12. J. Ivorra Cortés2,
  13. J. Fragio Gil2,
  14. I. Martínez Cordellat2,
  15. J. Valero Sanz2,
  16. I. Chalmeta Verdejo2,
  17. L. González Puig2,
  18. C. Alcañiz Escandell2,
  19. C. Nájera Herranz2,
  20. J. Castellano Cuesta3,
  21. J. Román Ivorra2
  1. 1Rheumatology Research Group, IIS la Fe
  2. 2Rheumatology Dept., HUP la Fe
  3. 3Rheumatology Dept., Hospital Arnau de Vilanova
  4. 4Biostatistics Unit, IIS la Fe, Valencia, Spain

Abstract

Background In the latest study published by the SEOM (Spanish Society of Medical Oncology) in 2012, the most prevalent types of cancers in Spanish women are breast, colorectal, corpus uteri, lung and ovary. In addition, in Systemic Lupus Erythematosus (SLE) patients a higher incidence of cancer has been described, about 15–20% higher. Today, there is some controversy around the activity on SLE or even drugs employed such as cyclophosphamide could be an extra risk factor for cancer development in these patients. In fact, there are not many studies regarding cancer incidence in SLE.

Objectives To analyze the cancer incidence in a series of SLE patients, as well as their clinical characteristics.

Methods Cross-sectional retrospective study of SLE patients according to the SLICC-2012 criteria, coming from the Rheumatology Service of Arnau de Vilanova Hospital and La Fe Hospital. In all patients clinical and disease activity data were collected, using personal interview and medical history.

Results A total of 140 patients were evaluated; of them, 95% were women with 33.39±13.63 year-old average at the diagnosis time with a 10.05±11.42 year-evolution of SLE. Of them, 6 patients (4.3%) have had some type of cancer, whose clinical characteristics are presented in the table.

Table 1

Conclusions The percentage of SLE patients who have developed any type of cancer was 4.3%, which doubles the rate for Spanish general population (2.12%). The types of found cancer are heterogeneous and don't correspond to the usual pattern described for general population in our country.

Disclosure of Interest None declared

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