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AB0455 Dyslipidemia and Atherogenic Risk in Patients with Systemic Lupus Erythematosus
  1. H.A. Radillo1,
  2. J.A. Batún1,
  3. E. Hernández2
  1. 1Internal Medicine
  2. 2Hospital de Alta Especialidad Dr. Gustavo A. Rovirosa Pérez, Villahermosa, Mexico

Abstract

Background Dyslipidemia is a common comorbidity in patients with systemic lupus erythematosus, it is favored by central obesity, nephrotic syndrome, glucocorticoids and immunosuppressants.

Methods 51 patients, who were determined the lipid profile were included. Variables associated with the disease and the drugs used were recorded. Atherogenic risk was calculated. Chi square was used for categorical variables. ANOVA was performed to determine the relationship between mean lipid profile and a logistic regression model to determine the association of the variables with the presence of dyslipidemia.

Results 68.6% had dyslipidemia. Significant difference between the presence of dyslipidemia and Activity index measured by SLEDAI (p=0.021) was found, the presence of lupus nephritis (P=0.021), use of prednisone ≥20 mg/day (p=0.0009), evolution disease <3 years (P=0.027). Significance between the absence of dyslipidemia and use of hydroxychloroquine (P=0.021) was found. Activity index ≥4 (RR 6.34; p=0.038) and the use of prednisone >20 mg/day (RR 6.67; p=0.036) were independently associated with the presence of dyslipidemia. The average of Castelli rate was 5.02±1.8, the Kannel index was 2.97±1.4 and triglyceride/HDL-C ratio was 5.24 ±3.3.

Conclusions Patients with systemic lupus erythematosus have a high prevalence of dyslipidemia and a high atherogenic rate, which increases cardiovascular risk significantly.

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Disclosure of Interest None declared

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