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AB0441 Neuropsychiatric Manifestations of Adult-Onset Systemic Lupus Erythematosus
  1. D. Ivanova1,
  2. G. Milev2,
  3. S. Nacheva3,
  4. I. Petrova3,
  5. G. Angov3,
  6. J. Petrova3,
  7. K. Stoyanova3
  1. 1University Hospital Sofiamed, Department of Rheumatology
  2. 2Department of Rheumatology, MU Kliment Ohridski, Sofia
  3. 3Department of Neurology, MU Sofia, University Hospital Alexandrovska, Sofia, Bulgaria


Background Evaluation of the diversity of Neuropsychiatric (NP) manifestations of adult-onset Systemic Lupus Erythematosus (SLE) for the period 2012–2014 (extended 2014–2015) is presented. The most common complications are migraine, cognitive and motor disorders, seizures, cerebrovascular disease

Methods Complete clinical, rheumatological and neurological evaluation was performed using SLEDAI-2K, BILAG 2004, SLICC/ACR Damage Index test batteries. Immunological blood tests include C3, C4, Serum Cryoglobulins, ANA, anti-β2 GP I-Ig G, anti-β2 GP I-Ig M, Anti-double stranded DNA, anti-RNP/Sm, anti-His., Ro (SSA), La (SSB), anti-CENT B, anti-ribosomal P, ANCA followed by lumbal puncture, neuropsychological testing, Doppler sonography, EMG and EEG, brain MRI/CT.

Results A total of 220 patients were longitudinally observed in 4 years period - 185 female, (84%), 35 men (16%). 82 (37%) patients presented NPSLE during the first 6 months. Consequent NP manifestations include: central vertigo (73.5%), headache (66.5%), cognitive impairment (33.2%), psychiatric disorders (18.7%), seizures (7.3%), cerebrovascular disease (10.6%), and polyneuropathy (3.5%). Positive anti-DNA antibodies (50%), anti-ribossomal P (20%), anticardiolipin antibodies (50%) were identified in NPSLE patients.

Conclusions Patients with SLE present with different NP manifestations. It is still difficult to provide accurate differential diagnosis between NPSLE and chronic cerebrovascular disease or MS especially when NP manifestations are the first symptoms of SLE.

Disclosure of Interest None declared

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