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AB0434 The Role of IGG Anti β2-GPI in The Clinical Manifestations of Systemic Lupus Erythematosus
  1. B. Mahendran,
  2. R. Sankalingam,
  3. K. Mohanasundaram,
  4. S. Sankaran,
  5. M. Mani,
  6. B. Chilukuri
  1. Rheumatology, Madras Medical College, Chennai, India

Abstract

Background Beta 2 GPI is an important antigenic target for antiphospholipid antibodies. The role of IgG antibodies to β2 glycoprotein I [Anti-β2-GPI] has been well defined in antiphospholipid antibody syndrome but its role in the clinical manifestions of SLE remains elusive.

Objectives To investigate the role of Anti-β2-GPI in the clinical manifestations of SLE

Methods IgG Anti-β2-GPI was measured in 184 patients with SLE (93% women, mean age 28 years). IgG Anti-β2-GPI (>18 GPL units) was found in 19 patients (10.3%). Associations were determined with clinical manifestations of SLE and with components of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index

Results Of the patients with SLE who demonstrated IgG Anti-β2-GPI, 31% had at least one thrombotic event (OR 4.2, p=0.01), 26% had pulmonary hypertension (OR 3.2, p=0.02) and 26% had recurrent abortions (OR 4.1, p=0.02). IgG Anti-β2-GPI was protective against lupus nephritis (OR 0.31, p=0.02). No other manifestations were significantly higher in patients with IgG Anti-β2-GPI positivity

Conclusions In SLE, IgG Anti-β2-GPI is associated with thrombotic events and pulmonary hypertension, but may have a protective effect against lupus nephritis. Large scale studies are required to confirm these findings.

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  3. Matsuura E, Shen L, Matsunami Y, Quan N, Makarova M, Geske FJ et al. Pathophysiology of beta2-glycoprotein I in antiphospholipid syndrome. Lupus. 2010 Apr;19(4):379–84.

Disclosure of Interest None declared

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