Background Biological therapies have demonstrated efficacy in patients with rheumatoid arthritis (RA) improving the prognosis. The most widely used biological agents are tumor necrosis factor inhibitors (TNFi), although other biological agents with different mechanisms of actions, such abatacept, have been approved. Although all these drugs are indicated in RA, there is limited data on their use and whether differences in baseline characteristics of RA patients treated with different biologics
Objectives To analyze differences in baseline characteristics of RA patients treated with abatacept, a T-cell co-stimulation inhibitor, compared with those treated with a TNFi
Methods All BIOBADASER 2.0 register patients diagnosed with RA and treated with abatacept from January 2008 to December 2014 were selected. Baseline sociodemographic and clinical characteristics were analyzed compared them with RA patients treated with TNFi during the same period. Variables analyzed: age; gender; disease duration; positivity of rheumatoid factor; disease activity at initiation of biological measured by the DAS-28 score; number of previous biological agents (0, 1, ≥2); and concomitant glucocorticoid treatment. Differences between abatacept and TNFi patients in baseline DAS28 were analyzed according to the number of previous biological drugs received
Results From January 2008 to December 2014, 252 RA patients treated with abatacept and 640 with TNFi were included in the BIOBADASER 2.0 register. Baseline characteristics are shown in Table1. At baseline, patients treated with abatacept were significantly younger; had a longer disease duration; had received a greater number of previous biologics; and had a higher DAS-28 (significant in patients who had received 1 previous biologic) than those treated with TNFi
Conclusions Patients with RA treated with abatacept have more active disease and a poorer prognosis that those treated with TNFi, significantly longer disease duration, have failed more previous biological agents and have higher baseline inflammatory activity
Disclosure of Interest None declared
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