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AB0329 Ultrasound 7 versus Ultrasound12 in Monitoring The Response To Adalimumab in Patients with Rheumatoid Arthritis
  1. S. Tropea,
  2. I. De Andres,
  3. P. Santonocito,
  4. A.A. Russo,
  5. E. Battaglia
  1. U.O. Rheumatology, Arnas Garibaldi, Catania, Italy

Abstract

Objectives This study aimed to assess the responsiveness of ultrasonography (US)-7 in patients with psoriasic arthritis (RA) non responders at only MTX terapy recruided with baseline ecographic positivity per disease activity. Sixty-two RA patients were recruited and followed up for 24 weeks.

Methods The clinical, laboratory, and X-ray assessments, along with grayscale US (GSUS) and power Doppler US (PDUS) examinations were performed at baseline, 6, 14, and 24 weeks after adalimumab treatment GSUS for synovitis and PDUS for synovitis and paratendinitis/tenosynovitis were assessed by a semi-quantitative (0 to 3) score, while GSUS for paratendinitis/tenosynovitis and bone erosion was qualitatively assessed as absent or present (0 or 1). US scores in both 7-joint (US7) and 12-joint (US12) systems were evaluated.

Results After 6, 14, and 24weeks of treatment with adalimumab, indices such as US scores in both 7-joint (US7) and 12-joint (US12) systems were evaluated. After 6, 14, and 24 weeks of treatment with adalimumab indices such as US scores, 28-joint disease activity (DAS28) score, and tender and swelling joint count were all significantly improved compared to baseline. US7 scores were significantly correlated with that of US12. Strong correlations were identified between most US7 scores with DAS28, health assessment questionnaire (HAQ), and C-reactive protein (CRP) levels. When DAS28 was used as a reference, the US7 cutoff for disease remission was less than 35 for GS+PD and also less than 29 for GS and 1 for PD, respectively

Conclusions Additionally, the positive percent agreement, negative percent agreement, and overall percent agreement for GS+PD were 77.78, 76.19, and 76.67%, respectively, which were all higher than that of GS or PD. US7 may be a feasible tool to assess the therapeutic response in RA patients.

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Disclosure of Interest None declared

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