Background There is no investigation of large joint destruction treated with golimumab in rheumatoid arthritis. Especially what clinical factors related to the inhibition of large joint destruction was not reported so far.
Objectives In order to investigate the inhibition of large joint destruction for rherumatoid arthritis in treated with golimumab, 450 large joints were assessed at baseline and 52 weeks after treatment with golimumab.
Methods 450 large joints from 45 patients including elbow, shoulder, hip, knee and ankle by using ARASHI (Assessment of rheumatoid arthritis by scoring of large joint destruction and healing in radiographic imaging) scoring system (1) at baseline and 52 weeks after treatment with golimumab. Baseline data were mean age of 61.29±14.71 years, 91.1% of female, mean disease duration of 12.6±12.48 years, stage/class of I:7,II:10,III:9:,IV:19/2:18,3:26,4:1, mean MTX of 6.44±1.78 mg/weeks, mean PSL of 1.078±1.871 mg/day, 44.4% of 100 mg for golimumab, mean DAS28 (CRP) of 4.431±1.044. Rapid radiographic progression (RRP) and rapid radiographic improvement (RRI) were calculated and analysis of correlation for large joint destruction and clinical factors between baseline and 52 weeks.
Results RRP was 21.9% in 450 large joints treated with golimumab. Therefore 78.1% were inhibited large joint destruction treated with goimumab in RA. RRI was 35.7% showing large joint improvement were obtained by golimumab. In clinical factors, baseline CRP affects ARASHI change score of knee at 52 weeks after treatment of golimumab.
Conclusions Inhibition of large joint destruction were obtained in 78.1% for the patients treated with golimumab in RA.
Kaneko A, et al. Development and validation of a new radiographic scoring system to evaluate bone and cartilage destruction and healing of large joints with rheumatoid arthritis: ARASHI (Assessment of rheumatoid arthritis by scoring of large joint destruction and healing in radiographic imaging) study. Modern Rheumatology 23:1053–62, 2013.
Disclosure of Interest None declared