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  • Can genetics explain the higher risk of worsening knee pain in offspring of people with total knee replacement for severe primary knee osteoarthritis?

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Correspondence
Can genetics explain the higher risk of worsening knee pain in offspring of people with total knee replacement for severe primary knee osteoarthritis?
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  1. Ting Zou1,
  2. Li Yang1,
  3. Ashley M Lee2,
  4. Xia Tan1,
  5. Elizabeth Wong2,
  6. Harrison X Bai2
  1. 1Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China
  2. 2Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
  1. Correspondence to Dr Li Yang, Department of Neurology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, P.R. China; yangli762{at}gmail.com

https://doi.org/10.1136/annrheumdis-2016-209380

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    We read with great interest a recent paper by Pan et al.1 The authors found that offspring of those with severe knee osteoarthritis (OA) had an increased risk of worsening knee pain over 8 years when compared with controls who had no family history of OA.1 Based on these results, the authors suggested that genetic factors may be involved in the pathogenesis of knee pain.1

    We commend the authors for performing a longitudinal study on the offspring of people with a total knee replacement (TKR) for severe OA. However, we would like to comment on several issues …

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