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We read with interest a recent paper by Stoffer et al1 on treat to target (T2T) evidence for rheumatoid arthritis (RA) published in the current issue of the journal.
The systematic literature review provided newer evidence by building on the existing 2010 T2T recommendations for RA.2 Based on this paper, the 2014 recommendation update was also published in the same issue. We congratulate the authors for performing thorough evidence summary. However, we would like to share a few concerns pertaining to the present paper.
The authors comment in their results section regarding the cost-effectiveness of the T2T strategy depending on a paper by Vermeer et al.3
Methotrexate monotherapy, when applied to patients with RA naïve to combination synthetic disease modifying anti rheumatic therapy (csDMARD), affords a disease activity score (DAS)28-based remission in 20%–25% patients …