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Five-year follow-up of radiographic sacroiliitis: progression as well as improvement?
  1. Alexandre Sepriano1,2,
  2. Martin Rudwaleit3,4,
  3. Joachim Sieper5,6,
  4. Rosaline van den Berg1,
  5. Robert Landewé7,8,
  6. Désirée van der Heijde1
  1. 1Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
  2. 2Department of Rheumatology, Hospital de Egas Moniz-CHLO, Lisbon, Portugal
  3. 3Klinikum Bielefeld and Charité, Berlin, Germany
  4. 4Gent University, Belgium
  5. 5Department of Rheumatology, Med Klinik I, Charité Campus Benjamin Franklin, Berlin, Germany
  6. 6German Rheumatism Research Centre, Berlin, Germany
  7. 7Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  8. 8Rheumatology Department, Atrium Medical Center, Heerlen, The Netherlands
  1. Correspondence to Dr Alexandre Sepriano, Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, Leiden 2300 RC, The Netherlands; alexsepriano{at}gmail.com

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Determining the presence of radiographic sacroiliitis is a key feature in the diagnostic process of radiographic axial spondyloarthritis (r-axSpA), synonymous to ankylosing spondylitis according to the modified New York criteria (mNY).1 Its presence is considered prognostically relevant and paves the way for treatment with biological drugs.2 Multiread and multireader exercises have proven that radiographic sacroiliitis is an ambiguous finding, as reflected by large inter-reader and intrareader variability.3 ,4

Determining progression of radiographic sacroiliitis, which marks the arbitrary but irreversible change from non-radiographic axSpA (nr-axSpA) to r-axSpA, is even more ambiguous. The mNY lack sensitivity-to-change in this slowly progressing condition, and it is conceivable that regression of radiographic sacroiliitis is very rare if not impossible.5 Previous studies addressing progression from nr-axSpA to r-axSpA have ignored regression and have only interpreted progression.6 However, from a methodological perspective, bi-directional change cannot be ignored.

The aim of this study was therefore to assess positive and negative changes on plain pelvic radiographs (X-SI) over time in the Assessment of SpondyloArthritis international Society (ASAS) cohort, in which X-SI judgements have been provided by single local readers from many centres worldwide.

In the ASAS cohort, 975 patients with either chronic back pain (>3 months, onset <45 years) of unknown origin or undiagnosed peripheral symptoms were assessed at baseline.7 ,8 Of these, 564 patients were reassessed after a mean follow-up of 4.4 years (range: 1.9–6.8). Patients with paired X-SI available (at baseline and follow-up) were included and judgements of the local observer (rheumatologist/radiologist) at both time points (either by the same or other reader) were analysed. Positive cases were defined as definite radiographic sacroiliitis according to the mNY.

In total, 357 patients had paired X-SI available. Of these, 17.4% (62/357) fulfilled the criteria for r-axSpA (table 1). At follow-up, this proportion has raised to 22.4% (80/357) suggesting a net progression of 5%. Cross-tabulation, however, revealed that more than half (36/62) considered mNY-positive at baseline were assessed mNY-negative at follow-up (table 2). If true, this would mean that radiographic sacroiliitis would have regressed in 58% of the cases. Conversely, only 54/295 patients (18.3%) became positive at follow-up.

Table 1

Baseline characteristics of patients with baseline and follow-up pelvic radiographs

Table 2

Radiographic sacroiliitis according to the modified New York criteria at baseline and at follow-up (on average 4.4 years)

It is very difficult to interpret these data, since progression, regression and measurement error (leading to spurious change) cannot be disentangled. Under the untenable assumption of ‘no true change’, the kappa statistic would yield a very poor figure of 0.21 (only marginally better than chance-agreement), which would make it useless from a diagnostic perspective.

If only positive change (progression) is valued and negative change is ignored, one would disregard measurement error and spuriously attribute part of the observed positive change to real progression.

The most likely explanation of our strange and extreme observation is that subtle radiographic progression (the signal)—if truly present—cannot be reliably distinguished from measurement error (the noise). These sobering data clearly illustrate that more research is needed in visualising progression in axSpA. Imaging modalities other than radiographs should be evaluated in future such as MRI and low-dose CT.

References

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Footnotes

  • Contributors All authors contributed to the study design and interpretation of data. AS was responsible for the statistical analysis and prepared the first version of the manuscript. All authors approved the final version of the manuscript.

  • Funding This study was financially supported by ASAS. AS received a research grant from ASAS for a fellowship, during which the study analysis was performed.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study has been approved by the local ethics committees. All patients provided written informed consent at the baseline visit that also included consent for the follow-up visit.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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