Article Text

PDF
Extended report
Analysis of periarticular bone changes in patients with cutaneous psoriasis without associated psoriatic arthritis
  1. David Simon1,
  2. Francesca Faustini1,
  3. Arnd Kleyer1,
  4. Judith Haschka1,2,
  5. Matthias Englbrecht1,
  6. Sebastian Kraus1,
  7. Axel J Hueber1,
  8. Roland Kocijan1,2,
  9. Michael Sticherling3,
  10. Georg Schett1,
  11. Jürgen Rech1
  1. 1Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
  2. 2Medical Department II, the VINFORCE Study Group, St. Vincent Hospital, Academic Teaching Hospital of Medical University of Vienna, Vienna, Austria
  3. 3Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany
  1. Correspondence to Dr Juergen Rech, Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen 91054, Germany; juergen.rech{at}uk-erlangen.de

Abstract

Objectives To search for structural bone changes in the joints of psoriasis patients without psoriatic arthritis (PsA).

Methods 55 psoriasis patients without any current or past symptoms of arthritis or enthesitis and 47 healthy controls were examined by high-resolution peripheral quantitative CT scans of the metacarpophalangeal joints. Number, size and exact localisation of erosions and enthesiophytes were recorded by analysing axial scans of the metacarpal heads and phalangeal bases and were confirmed in additional coronal and/or sagittal sections. In addition, we collected demographic and clinical data including subtype, duration and severity of psoriasis.

Results Psoriasis patients showed a larger and significantly increased number of enthesiophytes (total number 306; mean±SD/patient 5.62±3.30) compared with healthy controls (total number 138; mean±SD/patient 3.04±1.81, p<0.001). Enthesiophytes were typically found at the dorsal and palmar sides of the metacarpal heads where functional entheses related to extensor and flexor tendons are localised. Bone erosions were rare and not significantly different between psoriasis patients and healthy controls. If present, erosions were almost exclusively found at the radial side of the second metacarpal head in both psoriasis patients and healthy controls.

Conclusions Psoriasis patients without PsA show substantial signs of enthesiophyte formation compared with healthy controls. These changes represent new bone formation at mechanically exposed sites of the joint and substantiate the concept of the existence of a ‘Deep Koebner Phenomenon’ at enthesial sites in psoriasis patients.

  • Psoriatic Arthritis
  • Inflammation
  • Arthritis

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.