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Correspondence response
Response to: ‘Mutation in MMP2 gene may result in scleroderma-like skin thickening’ by Bader-Meunier et al
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  1. Siddharth Banka1,
  2. William G Newman2
  1. 1Manchester Centre for Genomic Medicine, Institute of Human Development, Manchester, UK
  2. 2Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK
  1. Correspondence to Dr Siddharth Banka, Manchester Centre for Genomic Medicine, Institute of Human Development, St Mary's Hospital, Manchester M13 9WL, UK; siddharth.banka{at}manchester.ac.uk

https://doi.org/10.1136/annrheumdis-2015-208538

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    MMP2 related disease (Multicentric osteolysis, nodulosis and arthropathy—MONA syndrome—OMIM #259600) consists of a continuous clinical spectrum in terms of severity.1 Even in the same affected individual, different features may present with varying severity (eg, nodulosis may be absent even with severe osteolysis). Till date less than 15 families with MMP2 mutations have been reported2 ,3 and, therefore, it is likely …

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