The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression

Tatsuya Atsumi; Kazuhiko Yamamoto; Tsutomu Takeuchi; Hisashi Yamanaka; Naoki Ishiguro; Yoshiya Tanaka; Katsumi Eguchi; Akira Watanabe; Hideki Origasa; Shinsuke Yasuda; Yuji Yamanishi; Yasuhiko Kita; Tsukasa Matsubara; Masahiro Iwamoto; Toshiharu Shoji; Toshiyuki Okada; Désirée van der Heijde; Nobuyuki Miyasaka; Takao Koike

doi:10.1136/annrheumdis-2015-207511

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Clinical and epidemiological research

Extended report

The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression

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	Abstract	Full	Pdf
Jul 2015	1720	391	601
Aug 2015	353	209	184
Sep 2015	161	170	122
Oct 2015	92	68	47
Nov 2015	101	132	80
Dec 2015	822	170	236
Jan 2016	830	188	227
Feb 2016	309	80	80
Mar 2016	225	66	77
Apr 2016	202	200	103
May 2016	180	72	102
Jun 2016	127	66	65
Jul 2016	113	69	74
Aug 2016	99	58	70
Sep 2016	111	68	62
Oct 2016	117	70	72
Nov 2016	114	74	87
Dec 2016	103	63	41
Jan 2017	111	56	58
Feb 2017	28	74	71
Mar 2017	11	76	49
Apr 2017	8	138	84
May 2017	10	160	65
Jun 2017	28	95	44
Jul 2017	123	120	53
Aug 2017	127	117	52
Sep 2017	111	105	28
Oct 2017	111	105	37
Nov 2017	178	168	37
Dec 2017	224	223	24
Jan 2018	231	229	37
Feb 2018	185	173	37
Mar 2018	179	171	30
Apr 2018	133	133	54
May 2018	145	146	31
Jun 2018	87	88	37
Jul 2018	95	89	36
Aug 2018	175	173	29
Sep 2018	78	78	13
Oct 2018	126	118	35
Nov 2018	121	119	23
Dec 2018	157	147	33
Jan 2019	97	92	14
Feb 2019	89	81	16
Mar 2019	89	69	28
Apr 2019	71	54	28
May 2019	54	49	14
Jun 2019	58	57	24
Jul 2019	72	65	26
Aug 2019	65	57	27
Sep 2019	56	52	21
Oct 2019	109	101	41
Nov 2019	64	54	19
Dec 2019	75	61	28
Jan 2020	73	57	29
Feb 2020	77	70	24
Mar 2020	56	46	20
Apr 2020	57	49	36
May 2020	71	64	75
Jun 2020	49	38	20
Jul 2020	60	54	25
Aug 2020	49	41	31
Sep 2020	70	62	41
Oct 2020	82	77	41
Nov 2020	70	50	22
Dec 2020	54	49	21
Jan 2021	46	42	17
Feb 2021	36	30	21
Mar 2021	60	51	29
Apr 2021	39	31	19
May 2021	41	37	24
Jun 2021	40	40	18
Jul 2021	36	36	27
Aug 2021	47	47	24
Sep 2021	34	33	19
Oct 2021	66	46	23
Nov 2021	65	57	32
Dec 2021	41	37	16
Jan 2022	64	52	17
Feb 2022	68	53	18
Mar 2022	91	81	20
Apr 2022	79	63	14
May 2022	97	89	38
Jun 2022	70	65	20
Jul 2022	59	48	24
Aug 2022	84	70	26
Sep 2022	136	78	50
Oct 2022	106	70	40
Nov 2022	111	95	33
Dec 2022	83	73	28
Jan 2023	87	70	33
Feb 2023	119	91	31
Mar 2023	116	102	46
Apr 2023	44	32	22
May 2023	79	58	31
Jun 2023	47	39	24
Jul 2023	60	50	27
Aug 2023	64	56	30
Sep 2023	44	37	21
Oct 2023	79	69	23
Nov 2023	88	77	19
Dec 2023	136	105	14
Jan 2024	76	75	23
Feb 2024	131	129	23
Mar 2024	48	37	27
Total	13045	9115	4989

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