Background The alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) have been previously investigated in patients with rheumatoid arthritis (RA); however their potential role on diseases activity has not been studied yet (1-2).
Objectives Presented study aimed to investigate the correlation of ALP and GGT with disease activity (as assessed by DAS28) and acute phase reactants in patients with RA.
Methods In total 81 newly diagnosed RA patients (male/female: 70/11), who fulfilled the 1987 American College of Rheumatology (ACR) classification criteria, as well as 32 healthy controls (male/female: 26/6) enrolled into study. Disease activity was assessed by DAS28. Demographic data, levels of ALP, GGT, and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and DAS28 scores were obtained from the patient files when first diagnosed and compared with each other.
Results Comparing RA patients with the control group, the ESR, and the levels of CRP, ALP and GGT were found higher in the RA group as compared to the control group. But only ESR and CRP levels were found statistical significance higher (p<0,05). Moreover, ALP, GGT levels were found to be positively correlated with ESR, and CRP levels (p<0,05).
Conclusions In this study we found that levels of ALP and GGT were correlated with ESR and CRP levels although DAS28 disease activity criteria wasn't found to be positively correlated with ALP and GGT levels. In RA patients levels of ALP and GGT may be used as disease activity indicators like ESR and CRP. However, more comprehensive studies are needed to make definite correlations between DAS 28, disease activity criteria, and levels of ALP and GGT.
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Pepys MB. Rheumatoid arthritis: The role of acute phase proteins. Br J Rheumatol 32 1993; (suppl 3): 1-2.
Disclosure of Interest None declared