Background Health Assessment Questionnaire (HAQ) is often used to assess functional disabilities, and is closely associated with disease activity and radiographic joint damage in patients with rheumatoid arthritis (RA)1. Joint range of motion (ROM) is also affected by inflammation and joint destruction in RA. However, the relationship between HAQ and large joint ROM still remains.
Objectives To examine the association of HAQ with clinical parameters including ROM of large joints in patients with RA.
Methods We have examined 62 patients with RA that were resistant to disease-modifying anti-rheumatic drugs (DMARDs). The mean age was 58.7 years and mean disease duration was 10.2 years. We measured ROM of cervical spine and large joints (bilateral shoulder, elbow, hip, knee and ankle joints), CRP, MMP-3 DAS28-ESR, SDAI, CDAI, degree of large joint damage (ARASHI status score2 and HAQ. Correlations of parameters were estimated by Spearman's rank correlation coefficient. Differences were considered significant if two-sided P-values were <0.05.
Results HAQ was well correlated with DAS28-ESR, SDAI and CDAI as expected. HAQ was not correlated with total ARASHI status score. However, HAQ was significantly correlated with shoulder flexion (r=0.38, P<0.01), shoulder abduction (r=0.37, P<0.01), elbow flexion (r=0.28, P<0.05) and ankle plantar flexion (r=0.27, P<0.05).
Conclusions We showed that HAQ was associated with ROM of large joint in patients with RA. Specifically, shoulder, elbow and ankle plantar flexion were important determinants of HAQ and, therefore, should be monitored to guide treatment.
Drossaers-Bal KW, et al. Arthritis Rheum. 1999; 42; 1854-1860.
Kaneko A, Matsushita I, et al. Mod Rheumatol. 2013; 23; 1053-1062.
Disclosure of Interest None declared