Background Anticyclic citrullinated peptide antibodies (ACCP) are considered a diagnosis criteria for rheumatoid arthritis (RA). However, it is unknown if there is a correlation between the levels of these antibodies and the disease activity, or their utility for the individual follow-up.
Objectives The aim of this study is to investigate the association between disease activity and levels of ACCP and rheumatoid factor (RF) in RA patients. As disease activity markers, Disease Activity Score (DAS28 PCR), Simplified Disease Activity Index (SDAI) and a Spanish version of the Health Assessment Questionnaire (HAQ) are used.
Methods DAS28 (PCR), SDAI and HAQ were evaluated in 62 sera of 42 RA patients, diagnosed according to the American College of Rheumatology/European League Against Rheumatism 2010 classification criteria. In all of them, AACP (Thermofisher) and RF were measured.
Results When we analyze the different correlations between AACP, RF and DAS28 (PCR), SDAI and HAQ, we find no correlation between then.
Figure 1: Pearson correlation (r) among serological data - anticyclic citrullinated peptide antibodies (ACCP) and rheumatoid factor (RF) - and clinical data - Disease Activity Score 28 (DAS28 PCR), Simplified Disease Activity Index (SDAI) and Health Assessment Questionnaire (HAQ) - in diagnosed RA patients.
Conclusions We find no correlation between serological and disease activity markers in RA patients. Consequently, although ACCP and RF are essential for the RA diagnosis, are not useful as disease activity indicators, and their continuous measurement in the monitoring of patients would not be indicated.
Disclosure of Interest None declared