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AB0153 Prevalence of HLA-B27 in Yakut Children with Seronegative Spondyloarthropathy
  1. V. Chasnyk1,
  2. F. Vinokurova2,
  3. L. Grigorieva2,
  4. V. Argunova3,
  5. A. Golderova2,
  6. T. Burtseva2,
  7. V. Nikolaev2,
  8. S. Efremova2,
  9. O. Tikhonova2
  1. 1Hospital Pediatrics, Saint-Petersburg State Pediatric Medical University, Saint-Petersburg
  2. 2Yakutia Research Center for Complex Medical Problems SB RAMS
  3. 3Yakutia National Centre of Medicine, Yakutsk, Russian Federation

Abstract

Background The term seronegative spondyloarthropathies (SpA) is used to define a specific group of disorders with certain common features, an increased incidence of HLA-B27, as well as negative rheumatoid factor and ANA being among them. The association of HLA-B27 within the group of SpA varies significantly, ranging from <50% in psoriatic, enteropathic, and inflammatory bowel disease-associated SpA, to 80% in reactive arthritis, to $><$ 50% in psoriatic, enteropathic and inflammatory bowel disease-associated SpA, to >95% in ankylosing spondilitis. The frequency of the HLA-B27 allele also varies widely across populations. The North-South and the East-West gradients are known with HLA-B27 high prevalence in Northern Eurasia and North America (10–16% of Scandinavians, 25–50% of Indigenous Northern Americans), and lower (2–6%) in Mediterranean regions, and decreasing prevalence from Southeast Asia (>12%) to China (1-6%) [1].

Objectives To determine the prevalence of HLA-B27 in Yakut children with SpA and in the population of healthy Yakuts

Methods The prevalence of HLA-B27 was studied among 75 unrelated Yakut children with SpA (mean age 10.2±0,5 years, 41 boys and 34 girls, otherwise healthy) and among unrelated healthy adult Yakuts (mean age 39.5±1,2, 56 men and 36 women) reflecting the general population of Yakutia. HLA typing was performed by means of a standard single specific primer - polymerase chain reaction (Amplikit-27, Russia).

Results In children association of SpA with HLA-B27 was revealed (p=0,022), 46,67% of them being HLA-B27 positive (OR =2, 22, CIOR: 1,17-4,22). Prevalence of HLA-B27 in total Yakut population was found to be 28.26%.

Conclusions Our results show low prevalence of HLA-B27 haplotype in Yakut children with SpA and rather high prevalence in the total population of Yakuts, being at the level of prevalence in Koriaks and Cukchi [2,3]. HLA-B27 is known to encompass many different alleles while SpA has thus far been documented in subjects possessing any one of the first several subtypes. Low prevalence of HLA-B27 in children with SpA makes it important to investigate which of them are specific for Yakut population

References

  1. Khan MA: HLA-B27 and its subtypes in world populations. Curr Opin Rheumatol 1995, 7:263–269.

  2. Pereverzeva VV. Prevalence of HLA-antigenes, genes and haplotypes in alien and native population of North-Eastern Russia. Diss. PhD. Tomsk, 2002: 191 pp. (in Russian)

  3. Krylov M., Erdesz S., Alexeeva L., Benevolenskaya L., Arnett F.C., J.D.Reveille. HLA Class II and HLA-B27 oligotyping in two native Siberian population groups. Tissue Antigens, 1995;46(5):382-6

Disclosure of Interest None declared

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