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AB0074 Interleukin-23 in Serum of Patients with Antineutrophil Cytoplasmic Antibody- Associated Systemic Vasculitis
  1. T.V. Beketova,
  2. E.N. Aleksandrova,
  3. N.O. Nikonorova,
  4. E.L. Nasonov
  1. V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation

Abstract

Background There is probably a systemic shift of cytokine production in patients with antineutrophil cytoplasmic antibody (ANCA)- associated systemic vasculitis (AAV) toward the Th17 cytokine response. We investigated whether interleukin-23 (IL-23), Th17- related cytokine, have any correlations with disease activity, clinical manifestations and treatment in AAV.

Objectives To analyse the concentration of interleukin-23 (IL-23) in serum of AAV patients, compared with healthy controls (HC).

Methods An enzyme- linked immunosorbent assay (ELISA) was used to analyse the serum concentration of IL-23 in 40 patients with AAV (median age 44 yrs (20- 65); F:M=1,11) and 8 HC (median age 47 yrs (21- 66); F:M=1,67). 23 patients were classified as granulomatosis with polyangiitis (GPA), 14- microscopic polyangiitis (MPA), and 3- eosinophilic granulomatosis with polyangiitis (EGPA). 26 patients were examined in active phase, 28- in remission (in 22/28 remission was induced by rituximab). The correlations between the levels of IL-23 and disease activity, clinical parameters were analysed.

Results The levels of IL-23 increased significantly in the serum of active PR3-ANCA patients before treatment compared with HC (median 41.9 pg/ ml and 13.1 pg/ ml, respectively, p<0,05). As immunosuppressive and anti B cell therapy (rituximab) in AAV patients resulted in effective suppression of serum IL-23 (5,2- 8,8 pg/ ml).

Table 1.

Characteristics of patients and controls

Conclusions There is a prospect further study of IL-23 and functionally similar cytokines in the pathogenesis of AAV.

Disclosure of Interest None declared

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