Background Anti-mullerian hormone (AMH) is a glycoprotein, secreted by granulose cells of follicles at the early developmental stage in ovaries (1,2). it was reported that AMH levels were more sensitive in indicating ovarian reserves, and as the number of follicles decreased with increasing age, AMH levels also decreased. AMH has been identified as a helper marker in ovarian reserve follow-ups in women with rheumatic diseases (3). FMF is encountered among the women with reproductive ages which should use colchicine as only effective treatment choice. In addition, another most important and controversial issue is fertility/infertility problem in this group.
Objectives To compare of ovarian reserves in attack-free familial Mediterranean fever (FMF) and healthy subjects by AMH, antral follicle number, ovarian volume, and hormonal parameters.
Methods Thirty-three-FMF patients aging 18-45 years, and 34 healthy women were enrolled and FSH, LH, E2, PRL, AMH levels were measured in the morning blood samples at 2nd-4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate antral follicle number and ovarian volumes.
Results In FMF group, median AMH levels were statistically significant lower in the M69V mutation positive group than in the negative ones (P=0.018) (Figure 1). No statistically significant difference in median AMH levels between E148Q mutation positive patients and the negative ones (P=0.920). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (P=0.868). No statistically significant difference was observed in median AMH levels between patients who had at least one mutation and those with no mutations (P=0.868). We found no difference in comparisons between ovarian volumes, number of follicles, and AMH levels (Figure 1), ovarian reserves when compared with FMF patients and healthy individuals.
Conclusions Ovarian reserves of FMF pateints were as similar as healthy subjects according to AMH. AMH levels were lower in FMF patients having M694V.
Cui Y, Shi Y, Cui L, Han T, Gao X, Chen ZJ. (2014) Age-specific serum antimullerian hormone levels in women with and without polycystic ovary syndrome. Fertil Steril 102:230-236.e2. doi: 10.1016/j.fertnstert.2014.03.032. Epub 2014 Apr 18.
Brouwer J, Laven JS, Hazes JM, Schipper I, Dolhain RJ. (2013) Levels of serum anti-mullerian hormone, a marker for ovarian reserve, in women with rheumatoid arthritis. Arthritis Care Res (Hoboken). 65:1534-1538. doi: 10.1002/acr.22013.
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Acknowledgements We would like to thank to Ziynet Çınar, M.D. for her statistical analysis.
Disclosure of Interest None declared