Background Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized with skin lesions and joint involvement. Mechanisms of developing early atherosclerosis in PsA patients is not elucidated yet. Salusin- α and salusin-β are two new bioactive molecules. Salusin-β has been reported to have pro-atherosclerotic effects, but salusin-α has anti-atherosclerotic effects. Mechanisms of atherosclerosis developing in PsA patients may be associated with salusins
Objectives The purpose of this study was to identify the serum salusin-α and salusin-β levels in patients with PsA and to determine the possible relationship with the disease findings.
Methods Forty patients diagnosed with PsA according to CASPAR classification criteria and 40healthy volunteers were included in the study. Demographic, clinical, laboratory and radiological data were recorded in all patients. Disease activity indexes (PASI, BASDAI, BASFI, HAQ) were recorded. Serum salusin-α and salusin-β level were measured by ELISA method.
Results Among 40PsA patients 13 (32.5%)were males and 27 (67.5%) were female, mean age was 48.5year and mean disease duration was 2.4 year. Demographic and clinical assessment of patients were as follows: 20 (50%) patients had family history, 18 (45%) patients were smoker, 19 (47.5%) patients had HLA-B27 positivity, 33 (82.5%) had sacroiliitis, 36 (90%) had enthesitis, 23 (57.5%) had DIP joints and nail involvement, 26 (65%) had wrist involvement, and 11 (27.5%) had ankle involvement. 20 (50%) patients had elevated CRP level and 25 (62.5%) patients had elevated ESR level. Compared with the control group PsA patients had elevated serum salusin-α level (p=0.004). The relationship between serum salusin-α level and ankle arthritis and dactylitis were determined (p=0.04, p=0.03). Serum levels of salusin-β were similar in PsA patients and controls (p=0.285). Serum salusin-β level were correlated with ankle arthritis (p=0.02).
Conclusions We found elevated serum salusin-α and normal serum salusin-β levels in PsA patients. Salusins may plays an important role in the pathogenesis of early atherosclerosis development in patients with PsA. In this regard, there is a need for multicenter prospective studies.
Disclosure of Interest None declared
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