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OP0053 Factors Associated with Early Loss to Follow-Up in a Multicenter Longitudinal Rheumatoid Arthritis Cohort
  1. D. Kim1,2,
  2. Y.-K. Sung1,2,
  3. S.-K. Cho1,2,
  4. C.-B. Choi1,2,
  5. S.-Y. Bang3,
  6. H.-S. Cha4,
  7. J.-Y. Choe5,
  8. W.T. Chung6,
  9. M. Her7,
  10. S.-J. Hong8,
  11. C.-I. Joung9,
  12. J.-B. Jun1,
  13. Y.O. Jung10,
  14. Y.M. Kang11,
  15. D.-Y. Kim7,
  16. H.-R. Kim12,
  17. H.A. Kim13,
  18. J. Kim14,
  19. S.-K. Kim5,
  20. T.-H. Kim1,
  21. T.-J. Kim15,
  22. E. Koh4,
  23. C.K. Lee16,
  24. H.-S. Lee3,
  25. J. Lee17,
  26. S.-H. Lee12,
  27. S.-H. Lee18,
  28. S.-S. Lee15,
  29. S.W. Lee6,
  30. Y.-A. Lee8,
  31. S.-S. Nah19,
  32. S.-H. Park5,
  33. D.H. Sheen20,
  34. S.-C. Shim21,
  35. G.G. Song22,
  36. C.-H. Suh13,
  37. D.-H. Yoo1,
  38. W.-H. Yoo23,
  39. B.Y. Yoon24,
  40. S.-C. Bae1,2
  1. 1Hanyang University Hospital for Rheumatic Diseases
  2. 2Clinical Research Center for Rheumatoid Arthritis, Seoul
  3. 3Hanyang University Guri Hospital, Guri
  4. 4Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul
  5. 5Catholic University of Daegu School of Medicine, Daegu
  6. 6Dong-A University Hospital
  7. 7Inje University Pusan Paik Hospital, Busan
  8. 8Kyung Hee University Hospital, Seoul
  9. 9Konyang University Hospital, Daejeon
  10. 10Hallym University Kangnam Sacred Heart Hospital, Seoul
  11. 11Kyungpook National University Hospital, Daegu
  12. 12Konkuk University Medical Center, Seoul
  13. 13Ajou University Hospital, Suwon
  14. 14Jeju National University Hospital, Jeju
  15. 15Chonnam National University Hospital, Gwangju
  16. 16Yeungnam University Hospital, Daegu
  17. 17Ewha Womans University Mokdong Hospital
  18. 18Kyung Hee University Hospital at Gangdong, Seoul
  19. 19Soonchunhyang University Cheonan Hospital, Cheonan
  20. 20Eulji University Hospital
  21. 21Chungnam National University Hospital, Daejeon
  22. 22Korea University Kuro Hospital, Seoul
  23. 23Chonbuk National University Hospital, Jeonju
  24. 24Inje University Ilsan Paik Hospital, Goyang, Korea, Republic Of

Abstract

Background Loss to follow-up can occur with many reasons, which influenced the outcomes of longitudinal cohort studies.

Objectives To compare the characteristics of patients who lost to follow-up and patients who completed the 2 years of follow-up, and examine the associated factors for early loss to follow-up (ELTF).

Methods The study subjects consisted of the KORONA cohort which is a multicenter longitudinal RA cohort. After excluding 1,119 patients who did not complete the 2 years of follow-up but still are actively participating, we divided the patients (n=4,257) into two groups; patients who lost to follow-up within 2 years (ELTF group), and patients who completed the 2 years of follow-up (FU group). Multivariate analysis was performed using the variables significant in univariate analyses and institutional factor. Institutions were divided in 3 groups based on the number of patients enrolled; A (largest) and C (smallest).

Results ELTF group patients (n=1,674, 39%) were older (p=0.04) and less educated (p<0.01). In a multivariate analysis, higher disease activity (OR 1.09, CI 1.02-1.16) and cardiovascular disease (CVD, OR 1.66, CI 1.17-2.34) at enrollment were risk factors for ELTF, whereas longer disease duration (OR 0.98, CI 0.97-0.99) and MTX use (OR 0.59, CI 0.49-0.70) were protective. Patients recruited from institutions of smaller numbers are likely to ELTF (C: OR. 7.65, CI 5.43-10.79, B: OR 3.27, CI 2.73-3.92, for A).

Conclusions RA Patient who have higher disease activity and CVD at enrollment are likely to ELTF, while longer disease duration and MTX use were protective. In addition, institutional factor should be considered as one of main factors for ELTF.

References

  1. Iannaccone CK, Fossel A, Tsao H, Cui J, Weinblatt M, Shadick N. Factors associated with attrition in a longitudinal rheumatoid arthritis registry. Arthritis Care Res (Hoboken). 2013;65(7):1183-9.

Disclosure of Interest None declared

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