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SAT0385 Disease Activity Patterns Over Time in Patients with SLE – a Retrospective Descriptive Analysis of the Hopkins Lupus Cohort
  1. N. Györi1,
  2. A. Chatzidionysiou1,
  3. L. Magder2,
  4. R. van Vollenhoven1,
  5. M. Petri2
  1. 1ClinTRID, Clinical Therapy Research, Inflammatory Diseases, Department of Medicine, Karolinska Institute, Stockholm, Sweden
  2. 2Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, United States

Abstract

Background Systemic Lupus Erythematosus (SLE) is a multi-systemic inflammatory disease, characterized by an extreme variability of its expression, both between individuals and within individuals, over time. Overall disease activity appears to be an important predictor of both mortality and organ damage. It is therefore important to understand the burden of disease course over time among patients with SLE (Barr et al. 1999)

Objectives To discern and describe SLE disease activity patterns over time by analyzing data from the Hopkins Lupus Cohort.

Methods Disease activity was retrospectively studied in a cohort of 2386 consecutive SLE patients followed up quarterly for 1-28 years (10 367 person-years of followup). SLE disease activity patterns were defined using 1) Physician Global Assessment (PGA) and 2) SLE Disease Activity Index (SLEDAI), including serology: Long Quiescent (LQ), SLEDAI/PGA=0 for 1 year at all visits; Relapsing-Remitting (RR), periods of disease activity (SLEDAI/PGA>0) interspersed with periods of disease inactivity (SLEDAI/PGA=0) at 1 or more visits during 1 year; Chronic Active (CA), SLEDAI/PGA scores are >0 for 1 year at all visits. Disease activity at yearly intervals (“1-year blocks”) was readily classified into 1 of the 3 major patterns for each patient. The pattern in each patient of 3 consecutive followup years (“3-year blocks”) was also determined: Persistent Long Quiescent (pLQ), LQ pattern in each of the 3 years; Persistent Remissing-Remitting (pRR), RR pattern in each of the 3 years; Persistent Chronic Active (pCA), CA pattern in each of the 3 years; Mixed, at least 2 different pattern types during 3 consecutive years. The frequency of different pattern groups (LQ, RR, CA) in each “1-year-block” and pattern subgroups (pLQ, pRR, pCA, Mixed) in each “3-year-block” of followup was examined.

Results Three major patterns of SLE disease activity were identified: LQ, RR, and CA. The RR pattern accounted for the greatest proportion of followup time for both the SLEDAI and PGA, representing 48.3% and 51.8% of total person-years, respectively. The CA pattern was the second most frequent pattern observed (SLEDAI 35.5%, PGA 38.5% of total person-years). The least prevalent pattern was the LQ (SLEDAI 16.1%, PGA 9.5% of total person-years), indicating that 655 patients experienced 1674 LQ “1-year-blocks”, and 352 patients experienced 981 LQ “1-year-blocks”, using SLEDAI and PGA, respectively. When disease activity was defined within 3-year intervals, the Mixed pattern was the most common for both the SLEDAI and LAI, representing 55% of total “3-year blocks”. The pRR and pCA patterns were intermediate and similar in frequency (pRR 19.8%, pCA 20.7%). The pLQ was the least frequent pattern (SLEDAI: 5.7% and PGA: 2.8%). The most common discrepancy between instruments was that the PGA demonstrated CA when the SLEDAI showed an RR pattern. The SLEDAI was more likely to depict the LQ pattern than was the PGA (Table 1.)

Conclusions In this large cohort, the three major patterns of SLE disease activity as originally identified by Barr et al. were confirmed. In the present study, the RR pattern appeared to be the most prevalent pattern type. Long quiescence was achieved in a subset of patients. Over a 3-year perspective almost half the patient maintained their disease activity pattern.

Disclosure of Interest None declared

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