Background Erectile dysfunction (ED) is prevalent among men with a variety of chronic medical conditions, including obesity, alcohol use, age, diabetes and cardiovascular disease. ED is caused by many factors such as psychogenic and organic (arteriogenic, cavernosal, neurogenic, anatomic and, endocrinologic) impairment. Gout is the most common inflammatory arthritis associated with subclinical endothelial dysfunction.
Objectives We investigated the status of ED in patients with gout who were using uric acid lowering agents and did not developed a flare-up, compared to healthy controls and studied correlation of ED with brachial-ankle pulse wave velocity and medical conditions of patients with gout.
Methods In this cross sectional study, total 208 male subjects were enrolled. Patients with well controlled gout (n=120) and health check-up controls (n=87). Erectile function was assessed by the International Index of Erectile Function (IIEF5) questionnaire. We checked brachial-ankle pulse wave velocity (baPWV), ankle brachial pressure index (ABI), heart rate variability (HRV) calculated by spectral analysis (high frequency (HF) and low frequency (LF)) and laboratory tests.
There was no significant difference in age, weight, smoking, alcohol, blood pressure, serum uric acid and HRV variables between patients group and healthy control group. In IIEF total score, control group was higher than gout patients (17.9±0.7 Vs 14.1±0.5, p<0.001). In patient group, IIEF total score 5 to 11, moderate to severe ED percent was higher than control group (34.3% Vs 11.4%, p<0.001). In moderate to severe ED group, age, duration of gout, and baPWV were higher than none or mild ED group (Table). In univariate and multiple logistic analysis for the prediction of ED, age (over 60), PWV (over 1550) represented high odd ratio (10.526, 7.152 respectively, p<0.001). After adjusted other variable factors, age and PWV were also independently associated with ED.
Conclusions The prevalence of ED is higher in patients with gout. Moderate to severe ED is associated with age, duration of gout, baPWV. Age and baPWV are independently associated with ED. The result of baPWV that assesses arterial stiffness is significantly correlated with ED for patients with gout
Disclosure of Interest None declared