Objectives To rate severity of lesions of extracranial and coronary arteries, depending on the bone mineral density (BMD) among men with coronary heart disease (CHD).
Methods 111 men aged 50-75 years [60 (55; 65) years old] with verified CHD were examined. By dual-energy absorptiometry at the femoral neck and lumbar spine BMD and the index T-criterion were measured. All patients were given coronary angiography (CAG) and quantification of coronary calcium using multislice computed tomography. Calcium index was determined by the Agatston method. Options for the defeat coronary arteries (CA) of one-, two-, and three-vessel and combination with the defeat of the trunk of the left CA (TrLCA) were evaluated. The intima-media thickness (IMT) was investigated according to duplex scanning of the extracranial arteries. Hemodynamically was significant narrowing of more than 50% of the diameter of the artery. Depending on the values of the T-criterion, patients were divided into 2 groups: I - with osteopenic syndrome (90 patients), aged 61 (55; 65) years old; II - with normal BMD (21 patients), aged 59 (55; 65) years old. According to the CAG isolated group of patients with severe lesions (stenosis of three CA and/or TrLCA) – type A and with stenosis of 1 or 2 CA - type B.
Results Osteopenic syndrome among men with CHD was detected in 81,1% of cases. IMT more than 1,0 mm identify 75,5% in group I and 66,7% in group II, p>0,05. Stenosis of more than 50% were detected at 56,7% in the 1st group and 38,1% of patients in group II, p>0,05. The marked negative correlation is between IMT and T-criterion of femur (r= -0,21; p=0,0299), and BMD of proximal femur (r= -0,2; p=0,0348). A significant positive correlation is between the number of diseased coronary arteries and IMT (r=0,3; p=0,0017). The values of total calcium score totaled 613,8 (256,8; 1097), 152.8 (0; 702,4), respectively, in groups I and II, with significant differences between groups I and II (p=0,0043). Indicator calcium score was significantly correlated with the number of diseased coronary arteries (r=0,24; p=0,0134). Severe coronary lesions (type A) was detected with 58 patients in group I (64,4%), 11 - in group II (52,4%), p>0,05. The values of total calcium score in type B among patients with normal BMD were significantly lower in comparison with a group of osteopenic syndrome and amounted to 0 (0; 152,8) and 768 (122,8; 1129,5), respectively (p=0,0041).
Conclusions Reduced bone mineral density among men correlates with atherosclerotic lesions of the extracranial arteries and is associated with calcification of the coronary arteries, which confirms the relationship between the osteopenic syndrome, atherosclerosis and vascular calcification with males.
Disclosure of Interest None declared
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