Article Text

PDF
SAT0022 Leptin as Prognostic Marker in Osteoarthritis Patients
  1. L. Seewordova,
  2. B. Zavodovsky,
  3. J. Polyakova,
  4. Y. Akhverdyan,
  5. V. Kravtsov,
  6. E. Simakova
  1. Rheumatology, Research Institute of Clinical end Experimental Rheumatology, Volgograd, Russian Federation

Abstract

Background In recent years, much attention is paid to the study of the relationship between degenerative joint diseases and adipokines. It is supposed that imbalance of adipokines may influence on the course of osteoarthritis (OA).

Objectives To study the clinical and pathogenetic significance of leptin determination in serum of OA patients.

Methods We observed 130 OA patients aged 34 to 78 years (78 women and 52 men). The control group consisted of 25 women and 20 men aged 26 to 58 years with no complaints of pain in the joints, and without clinical manifestations of OA. Groups did not differ by sex and age (t =0,54, p>0,05; t =0,29, p>0,05, respectively). To assess the state of the joints we used WOMAC, Lequesne, Dreiser functional indexes. Intensity of pain, duration and severity of stiffness, functional capacity of the patient were assessed by visual analogue scale (VAS). The indices were evaluated by questionnaire responses with gradation on a point system, the results were taken into account by the amount of indicators. All patients underwent X-ray and ultrasound examination of the joints. Leptin level in serum were determined by ELISA test (BioVendor, cat No. CAN-L-4260) before and after treatment.In recent years, much attention is paid to the study of the relationship between degenerative joint diseases and adipokines. It is supposed that imbalance of adipokines may influence on the course of osteoarthritis (OA).

Results Leptin level in serum of healthy men was 3,8±0,21 ng/ml, in healthy women 7,4±0,37 ng/ml (here and further M±m). Gender differences were statistically significant (p<0,001, t=7,91). Elevated leptin level was detected in 33 OA female patients (25.4%). Leptin in women with OA was 14,4±0,32 ng/ml. Elevated leptin levels was detected in nine men with OA (6.9%). Leptin levels in men with OA was 6,2±0,25 ng/ml. As men as woman with OA and high levels of leptin (more than 11.1 ng/ml and 5.6 ng/ml respectively) was more likely to have Heberden and Bouchard nodes, secondary synovitis, duration of disease more than 10 years, higher radiographic stage and functional impairment of the joints. We revealed statistically significant relationship between leptin levels in serum of patients with OA and concentration of C-reactive protein, erythrocyte sedimentation rate, WOMAC and Lequesne indexes.

Conclusions Thus, we revealed elevated leptin level in serum of 42 patients with OA (32.3%). As men and women with OA with increased leptin levels had severe form of the disease. Thus leptin may have important significance in pathogenesis of OA.

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.