Article Text

PDF
FRI0581 Utility of the Glasgow Prognostic Score in Systemic Lupus Erythematosus, In a Single Center Cohort of 130 Patients
  1. C. Delcea1,1,2,2,
  2. A. Dima1,2,
  3. C. Jurcut3,4,
  4. S. Caraiola1,2,4,
  5. C. Badea1,2,4,
  6. D. Nitescu1,2,
  7. E. Balanescu1,2,
  8. A. Nicolau1,2,4,
  9. V. Pompilian1,
  10. R. Ionescu1,2,4,
  11. C. Baicus1,2,4,
  12. G.A. Dan1,2,4
  1. 1Internal Medicine, Colentina Clinical Hospital
  2. 2Colentina Research Center
  3. 3Internal Medicine, “Dr Carol Davila” Central University Emergency Military Hospital
  4. 4“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

Abstract

Background Glasgow Prognostic Score (GPS) is a simple, systemic inflammation-based prognostic score used mostly in oncology and intensive-care.

Objectives We aimed to investigate the utility of GPS in assessing disease activity in patients with systemic lupus erythematosus (SLE).

Methods Patients admitted consecutively to our department were prospectively enrolled in the study. Clinical and biological parameters were assessed in each participant. Disease activity was quantified using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Systemic Lupus Activity Measure (SLAM) and European Consensus Lupus Activity Measurement (ECLAM). GPS was calculated using 1 point for C reactive protein>10mg/L and 1 point for hypoalbuminemia.

Results Our study group included 130 patients with a mean age of 46.58±12.69 years old and 90% female predominance, out of which 17 (13.07%) had a GPS≥1. Median ECLAM score was 2[0-7.5], median SLAM score was 4[0-24] and median SLEDAI score 6[0-48]. Patients with a GPS≥1 had a higher ECLAM score compared to those with a GPS=0 (3[0-10.5] vs. 2[0-7], p=0.007), a higher SLAM score (7[0-22] vs. 4[1-14], p=0.003), a higher SLEDAI score (8[0-48] vs. 4.5[0-30], p=0.006) and a higher erythrocyte sedimentation rate (ESR) (24[10-90] vs. 13.5[2-61], p=0.03). ROC curve analysis identified ECLAM and SLAM scores as predictors of a GPS≥1 with an AUC of 0.825 (95%CI 0.0.686-0.964, p=0.01) and 0.740 (95%CI 0.483-0.998, p=0.07) respectively. Elevated ESR was also associated with a GPS≥1 with an AUC of 0.819 (95%CI 0.693-0.945, p=0.01).

Conclusions GPS was correlated with disease activity in patients with SLE. A simple systemic inflammation score, it could be used as an auxiliary tool for their assessment.

Acknowledgements This paper is supported by POSDRU/159/1.5/S/137390.

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.